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nhr-48 Nuclear hormone receptor family member nhr-48;Nuclear receptor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181661, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-48
Official Full Name
Nuclear hormone receptor family member nhr-48;Nuclear receptor domain-containing protein
Primary source
WormBase:WBGene00003638
Locus tag
CELE_ZK662.3
See related
AllianceGenome:WB:WBGene00003638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior gonad arm and spermatheca. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-48 in Genome Data Viewer
Location:
chromosome: X
Exon count:
16
Sequence:
Chromosome: X; NC_003284.9 (15708213..15716875)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein Neighboring gene Secreted protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear receptor nhr-48 is required for pathogenicity of the second stage (J2) of the plant parasite Meloidogyne incognita. Lu CJ, et al. Sci Rep, 2016 Oct 20. PMID 27762328, Free PMC Article
  2. daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Antebi A, et al. Genes Dev, 2000 Jun 15. PMID 10859169, Free PMC Article
  3. Transcriptional regulation of HLH-6-independent and subtype-specific genes expressed in the Caenorhabditis elegans pharyngeal glands. Ghai V, et al. Mech Dev, 2012 Sep-Dec. PMID 22759833
  4. Restriction of Cellular Plasticity of Differentiated Cells Mediated by Chromatin Modifiers, Transcription Factors and Protein Kinases. Rahe DP, et al. G3 (Bethesda), 2019 Jul 9. PMID 31088904, Free PMC Article
  5. H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Methot SP, et al. Nat Cell Biol, 2021 Nov. PMID 34737442, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-48;Nuclear receptor domain-containing protein
NP_001361843.1
  • Confirmed by transcript evidence
NP_001361880.1
  • Confirmed by transcript evidence
NP_001362159.1
  • Confirmed by transcript evidence
NP_001362160.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15708213..15716875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001375188.2 → NP_001361843.1  Nuclear hormone receptor family member nhr-48 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94407, Q9BJL1, Q9BJL2
    Conserved Domains (1) summary
    cd06966
    Location:108 → 200
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers

  2. NM_001375189.1 → NP_001361880.1  Nuclear hormone receptor family member nhr-48 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94407, Q9BJL1, Q9BJL2
    Conserved Domains (1) summary
    cd06966
    Location:108 → 200
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers

  3. NM_001375186.3 → NP_001362159.1  Nuclear receptor domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94407, Q9BJL1, Q9BJL2
    UniProtKB/TrEMBL
    A0A5E4LZF8
    Conserved Domains (1) summary
    cd06966
    Location:108 → 200
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers

  4. NM_001375187.3 → NP_001362160.1  Nuclear receptor domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94407, Q9BJL1, Q9BJL2
    UniProtKB/TrEMBL
    A0A5E4LX31
Nucleotide Protein
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