tbb-4 Tubulin beta-4 chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tbb-4
Official Full Name: Tubulin beta-4 chain
Primary source: WormBase:WBGene00006538
Locus tag: CELE_B0272.1
See related: AllianceGenome:WB:WBGene00006538
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in axonemal microtubule. Is expressed in accessory cell; epithelial cell; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness; complex cortical dysplasia with other brain malformations 5; complex cortical dysplasia with other brain malformations 6; complex cortical dysplasia with other brain malformations 7; and congenital symmetric circumferential skin creases 1. Orthologous to several human genes including TUBB4B (tubulin beta 4B class IVb). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See tbb-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (9434452..9436893, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Continual transport of sub-stoichiometric numbers of these TBB-4/TBA-5 subunits by the kinesin-2 dependent intraflagellar transport machinery can maintain sensory cilia at their steady-state length.
Title: Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0272.1 (e-PCR)
- UniSTS:308837

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axonemal microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tubulin beta-4 chain

NP_509585.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9434452..9436893 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077184.8 → NP_509585.1 Tubulin beta-4 chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509585.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41937

Conserved Domains (1) summary

PLN00220
Location:1 → 444

PLN00220; tubulin beta chain; Provisional