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Gpc2 glypican 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171517, updated on 10-Jul-2024

Summary

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Official Symbol
Gpc2provided by RGD
Official Full Name
glypican 2provided by RGD
Primary source
RGD:621363
See related
EnsemblRapid:ENSRNOG00000001367 AllianceGenome:RGD:621363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in neuron differentiation; positive regulation of neuron projection development; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface and synapse. Orthologous to human GPC2 (glypican 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 12.2), Testes (RPKM 12.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpc2 in Genome Data Viewer
Location:
12q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22391489..22397822, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17277875..17284297, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19593041..19599374, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene STAG3 cohesin complex component Neighboring gene uncharacterized LOC134481272 Neighboring gene PVR related immunoglobulin domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix. Paveliev M, et al. Sci Rep, 2016 Sep 27. PMID 27671118, Free PMC Article
  2. Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. Stipp CS, et al. J Cell Biol, 1994 Jan. PMID 8294498, Free PMC Article
  3. Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth. Kurosawa N, et al. Glycoconj J, 2001 Jun. PMID 12084985
  4. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Williams EH, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20231458, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glypican-2
Names
HSPG M13
cerebroglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138511.2 → NP_612520.1  glypican-2 precursor

    See identical proteins and their annotated locations for NP_612520.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    P51653
    UniProtKB/TrEMBL
    A6KSU5, A6KSU6
    Related
    ENSRNOP00000001849.2, ENSRNOT00000001849.6
    Conserved Domains (1) summary
    pfam01153
    Location:22 → 565
    Glypican; Glypican

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    22391489..22397822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089053.2 → XP_038944981.1  glypican-2 isoform X2

    Conserved Domains (1) summary
    pfam01153
    Location:1 → 320
    Glypican

  2. XM_039089052.2 → XP_038944980.1  glypican-2 isoform X2

    Conserved Domains (1) summary
    pfam01153
    Location:1 → 320
    Glypican

  3. XM_039089054.2 → XP_038944982.1  glypican-2 isoform X2

    Conserved Domains (1) summary
    pfam01153
    Location:1 → 320
    Glypican

  4. XM_039089051.2 → XP_038944979.1  glypican-2 isoform X1

    Conserved Domains (1) summary
    pfam01153
    Location:22 → 437
    Glypican
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51653.1 GenPept UniProtKB/Swiss-Prot:P51653

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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