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Khsrp KH-type splicing regulatory protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 171137, updated on 17-Aug-2024

Summary

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Official Symbol
Khsrpprovided by RGD
Official Full Name
KH-type splicing regulatory proteinprovided by RGD
Primary source
RGD:621828
See related
EnsemblRapid:ENSRNOG00000047628 AllianceGenome:RGD:621828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Marta1
Summary
Enables mRNA 3'-UTR binding activity. Predicted to be involved in several processes, including miRNA metabolic process; negative regulation of cellular biosynthetic process; and negative regulation of low-density lipoprotein particle clearance. Predicted to act upstream of or within mRNA catabolic process and regulation of miRNA metabolic process. Located in dendrite; neuronal cell body; and nucleus. Orthologous to human KHSRP (KH-type splicing regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 83.9), Thymus (RPKM 69.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Khsrp in Genome Data Viewer
Location:
9q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1949557..1959400, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1862555..1872403, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10013795..10023670)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene alkB homolog 7 Neighboring gene persephin Neighboring gene general transcription factor IIF subunit 1 Neighboring gene adenylate kinase isoenzyme 5 Neighboring gene solute carrier family 25, member 41 Neighboring gene solute carrier family 25 member 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spatiotemporal expression of KHSRP modulates Schwann cells and neuronal differentiation after sciatic nerve injury. Zhu X, et al. Int J Biochem Cell Biol, 2014 Mar. PMID 24368152
  2. K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer. Bikkavilli RK, et al. J Biol Chem, 2017 May 5. PMID 28275056, Free PMC Article
  3. Molecular characterization of MARTA1, a protein interacting with the dendritic targeting element of MAP2 mRNAs. Rehbein M, et al. J Neurochem, 2002 Sep. PMID 12358751
  4. KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons. Bird CW, et al. PLoS One, 2013. PMID 24244461, Free PMC Article
  5. The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells. Connerty P, et al. Biochim Biophys Acta, 2016 Oct. PMID 27478153

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
    Title: KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
  2. Authors speculated that KHSRP was involved in SCs and neuronal differentiation by inducing beta-catenin mRNA decay.
    Title: Spatiotemporal expression of KHSRP modulates Schwann cells and neuronal differentiation after sciatic nerve injury.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in 3'-UTR-mediated mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA stability ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of miRNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
far upstream element-binding protein 2
Names
FUSE-binding protein 2
KSRP
MAP2 RNA trans-acting protein 1
MAP2 RNA trans-acting protein MARTA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395096.1 → NP_001382025.1  far upstream element-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q99PF5
    UniProtKB/TrEMBL
    A0A0G2K2B3
    Related
    ENSRNOP00000072174.2, ENSRNOT00000077653.3
    Conserved Domains (5) summary
    pfam09005
    Location:672 → 686
    DUF1897; Domain of unknown function (DUF1897)
    cd22479
    Location:146 → 216
    KH-I_FUBP2_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22482
    Location:234 → 306
    KH-I_FUBP2_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22485
    Location:324 → 391
    KH-I_FUBP2_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
    cd22488
    Location:427 → 495
    KH-I_FUBP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    1949557..1959400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133602.1: Suppressed sequence

    Description
    NM_133602.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PF5.1 GenPept UniProtKB/Swiss-Prot:Q99PF5

Gene LinkOut

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