Ppp1r15a protein phosphatase 1, regulatory subunit 15A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r15aprovided by RGD
Official Full Name: protein phosphatase 1, regulatory subunit 15Aprovided by RGD
Primary source: RGD:621526
See related: AllianceGenome:RGD:621526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Peg-3; Gadd34; Myd116; RGD1624209
Summary: Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular response to nutrient levels; cellular response to organonitrogen compound; and regulation of cellular protein metabolic process. Located in cytosol. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 157.5), Heart (RPKM 149.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105136521..105139596, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96000053..96003128, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101511899..101515043, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes.
Title: Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes.
Following restraint stress, there was rapid induction of GADD34 in brain.
Title: Psychological stress, cocaine and natural reward each induce endoplasmic reticulum stress genes in rat brain.
results show that GADD34 plays an important role in cell protection in mutant huntingtin expressing cells
Title: GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway.
GADD34 has the potential to influence cell survival in ischaemically compromised tissue.
Title: Evolution of GADD34 expression after focal cerebral ischaemia.
The inherent property of PEG-3 to function as a dominant negative of the growth inhibitory property of GADD34 might rescue cells from DNA damage-induced apoptosis leading to growth independence and tumorigenesis.
Title: Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3).
After transient cerebral ischemia GADD34 protein levels were increased in the cortex but not in the hippocampal CA1 subfield; these changes occurred earlier in SOD1 transgenic than in wild-type animals; rise in gadd34 mRNA levels did not differ [GADD34]
Title: GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post-ischemic recovery of protein synthesis in ischemia-resistant cells.
PEG-3 plays a central role in augmenting tumor progression by modulating several critical parameters of the carcinogenic process, such as genomic stability and local tumor cell invasion.
Title: Progression elevated gene-3 (PEG-3) induces pleiotropic effects on tumor progression: modulation of genomic stability and invasion.
PEG-3 does not exist in normal rat cells, which have a single diploid complement of Gadd34. Sequence analysis of the rat Gadd34 gene & comparison with PEG-3 indicates that PEG-3 is most likely a mutant of Gadd34.
Title: Gadd34 functional domains involved in growth suppression and apoptosis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to calcium ion starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to carbohydrate stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cordycepin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to desipramine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to gold(3+)	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to methamphetamine hydrochloride	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to methyl methanesulfonate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein modification process	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to environmental enrichment	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 1 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 15A

Names: growth arrest and DNA damage-inducible protein GADD34; myeloid differentiation primary response gene 116; myeloid differentiation primary response protein MyD116 homolog; progression elevated gene 3 protein; protein phosphatase 1, regulatory (inhibitor) subunit 15A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133546.3 → NP_598230.2 protein phosphatase 1 regulatory subunit 15A

See identical proteins and their annotated locations for NP_598230.2

Status: VALIDATED

Source sequence(s)

BC072513, JAXUCZ010000001

UniProtKB/Swiss-Prot

O88344, Q6IN02, Q7TQC2

UniProtKB/TrEMBL

A0A0G2JSW4, A6JB49

Conserved Domains (1) summary

pfam10488
Location:459 → 526

PP1c_bdg; Phosphatase-1 catalytic subunit binding region