Cd79b CD79b molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd79bprovided by RGD
Official Full Name: CD79b moleculeprovided by RGD
Primary source: RGD:620012
See related: AllianceGenome:RGD:620012
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: B29; Igb
Summary: Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in B cell differentiation and B cell receptor signaling pathway. Predicted to act upstream of or within response to bacterium. Predicted to be part of IgM B cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia 6 and lymphoma (multiple). Orthologous to human CD79B (CD79b molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 956.6) and Thymus (RPKM 107.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91739134..91742312, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (91239354..91242500, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94497445..94500591, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNAse I hypersensitive sites were shown to have enhancer activity with respect to the rat B29/Ig-beta gene.
Title: Novel regulatory regions found downstream of the rat B29/Ig-beta gene.
Data indicate that the GH locus-embedded, tissue-specific B29 gene is silenced in GH-expressing pituitary cells by epigenetic mechanisms, the lack of a B cell-specific transcription factor, and by the B29 3' enhancer acting as a tissue-specific silencer.
Title: B29 gene silencing in pituitary cells is regulated by its 3' enhancer.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of B cell receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of B cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of IgM B cell receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell antigen receptor complex-associated protein beta chain

Names: CD79B antigen; Cd79b molecule, immunoglobulin-associated beta; immunoglobulin-associated beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133533.2 → NP_598217.1 B-cell antigen receptor complex-associated protein beta chain precursor

See identical proteins and their annotated locations for NP_598217.1

Status: PROVISIONAL

Source sequence(s)

BC088115

UniProtKB/TrEMBL

F1MAP5, O70153

Conserved Domains (3) summary

smart00077
Location:192 → 211

ITAM; Immunoreceptor tyrosine-based activation motif

smart00410
Location:61 → 141

IG_like; Immunoglobulin like

cl11960
Location:55 → 141

Ig; Immunoglobulin domain