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Znrf1 zinc and ring finger 1 [ Mus musculus (house mouse) ]

Gene ID: 170737, updated on 18-Sep-2024

Summary

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Official Symbol
Znrf1provided by MGI
Official Full Name
zinc and ring finger 1provided by MGI
Primary source
MGI:MGI:2177308
See related
Ensembl:ENSMUSG00000033545 AllianceGenome:MGI:2177308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnf42; Zrfp1; nin283; B830022L21Rik
Summary
Enables ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytosol; endosome; and membrane. Is expressed in central nervous system; genitourinary system; and retina nuclear layer. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 159.2), whole brain E14.5 (RPKM 40.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Znrf1 in Genome Data Viewer
Location:
8 E1; 8 57.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112262652..112352352)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111536484..111625720)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22695 Neighboring gene predicted gene, 24793 Neighboring gene WD repeat domain 59 Neighboring gene STARR-positive B cell enhancer ABC_E112 Neighboring gene STARR-seq mESC enhancer starr_22698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114079308-114079417 Neighboring gene STARR-positive B cell enhancer ABC_E5041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114087696-114087913 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114116137-114116338 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114119771-114119993 Neighboring gene STARR-seq mESC enhancer starr_22705 Neighboring gene STARR-positive B cell enhancer ABC_E9323 Neighboring gene STARR-positive B cell enhancer ABC_E885 Neighboring gene STARR-positive B cell enhancer ABC_E5042 Neighboring gene STARR-seq mESC enhancer starr_22707 Neighboring gene lactate dehydrogenase D Neighboring gene STARR-seq mESC enhancer starr_22708 Neighboring gene zinc finger protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10523 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Src-ZNRF1 axis controls TLR3 trafficking and interferon responses to limit lung barrier damage. Lin YS, et al. J Exp Med, 2023 Aug 7. PMID 37158982, Free PMC Article
  2. The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation. Lee CY, et al. Nat Commun, 2017 Jun 8. PMID 28593998, Free PMC Article
  3. Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration. Wakatsuki S, et al. J Cell Biol, 2015 Nov 23. PMID 26572622, Free PMC Article
  4. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. Araki T, et al. J Biol Chem, 2001 Sep 7. PMID 11427537
  5. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. Araki T, et al. J Neurosci, 2003 Oct 15. PMID 14561866, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1.
    Title: The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation.
  2. up-regulation of ZNRF1 activity by oxidative stress leads to neuronal apoptosis and Wallerian degeneration.
    Title: Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration.
  3. The ZNRF1-AKT-GSK3B-CRMP2 pathway plays an important role in controlling Wallerian degeneration.
    Title: ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC101991

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of autophagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of autophagosome-lysosome fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ZNRF1
Names
RING-type E3 ubiquitin transferase ZNRF1
nerve injury-induced gene 283 protein
peripheral nerve injury protein nin283
ring finger protein 42
zinc ring finger protein 1
zinc/RING finger protein 1
NP_001162092.1
NP_001162093.1
NP_001162094.1
NP_001350417.1
NP_001350418.1
NP_573469.1
XP_036009665.1
XP_036009666.1
XP_036009667.1
XP_036009668.1
XP_036009669.1
XP_036009670.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168621.3 → NP_001162092.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

    See identical proteins and their annotated locations for NP_001162092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS22676.1
    UniProtKB/Swiss-Prot
    Q8C5D7, Q91V17
    Related
    ENSMUSP00000126684.2, ENSMUST00000168428.8
    Conserved Domains (1) summary
    cd16694
    Location:182 → 227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  2. NM_001168622.3 → NP_001162093.1  E3 ubiquitin-protein ligase ZNRF1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS52673.1
    UniProtKB/TrEMBL
    E9PZB7
    Related
    ENSMUSP00000127956.2, ENSMUST00000171182.8
    Conserved Domains (1) summary
    cd16694
    Location:150 → 195
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  3. NM_001168623.2 → NP_001162094.1  E3 ubiquitin-protein ligase ZNRF1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 6 both encode the same isoform (c).
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS52674.1
    UniProtKB/TrEMBL
    E9PWL2
    Related
    ENSMUSP00000132939.2, ENSMUST00000166859.8
    Conserved Domains (1) summary
    cd16694
    Location:82 → 127
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  4. NM_001363488.2 → NP_001350417.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS22676.1
    UniProtKB/Swiss-Prot
    Q8C5D7, Q91V17
    Related
    ENSMUSP00000133993.2, ENSMUST00000173506.8
    Conserved Domains (1) summary
    cd16694
    Location:182 → 227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  5. NM_001363489.1 → NP_001350418.1  E3 ubiquitin-protein ligase ZNRF1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 4, encodes isoform c.
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS52674.1
    UniProtKB/TrEMBL
    E9PWL2
    Related
    ENSMUSP00000134634.2, ENSMUST00000174333.8
    Conserved Domains (1) summary
    cd16694
    Location:82 → 127
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  6. NM_133206.5 → NP_573469.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

    See identical proteins and their annotated locations for NP_573469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS22676.1
    UniProtKB/Swiss-Prot
    Q8C5D7, Q91V17
    Related
    ENSMUSP00000092799.6, ENSMUST00000095176.12
    Conserved Domains (1) summary
    cd16694
    Location:182 → 227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

RNA

  1. NR_156703.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC122364, AC127356

  2. NR_156704.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC122364, AC127356

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    112262652..112352352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153772.1 → XP_036009665.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C5D7, Q91V17
    Conserved Domains (1) summary
    cd16694
    Location:182 → 227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  2. XM_036153773.1 → XP_036009666.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C5D7, Q91V17
    Conserved Domains (1) summary
    cd16694
    Location:182 → 227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  3. XM_036153774.1 → XP_036009667.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C5D7, Q91V17
    Related
    ENSMUSP00000133309.2, ENSMUST00000172856.8
    Conserved Domains (1) summary
    cd16694
    Location:182 → 227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  4. XM_036153775.1 → XP_036009668.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

    UniProtKB/TrEMBL
    E9PZB7
    Conserved Domains (1) summary
    cd16694
    Location:150 → 195
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  5. XM_036153776.1 → XP_036009669.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

    UniProtKB/TrEMBL
    E9PZB7
    Conserved Domains (1) summary
    cd16694
    Location:150 → 195
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  6. XM_036153777.1 → XP_036009670.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

    UniProtKB/TrEMBL
    E9PZB7
    Conserved Domains (1) summary
    cd16694
    Location:150 → 195
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91V17.1 GenPept UniProtKB/Swiss-Prot:Q91V17

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