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Slc5a6 solute carrier family 5 member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170551, updated on 14-Nov-2024

Summary

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Official Symbol
Slc5a6provided by RGD
Official Full Name
solute carrier family 5 member 6provided by RGD
Primary source
RGD:69648
See related
EnsemblRapid:ENSRNOG00000057628 AllianceGenome:RGD:69648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SMVT
Summary
Enables sodium-dependent multivitamin transmembrane transporter activity. Involved in biotin transport and pantothenate transmembrane transport. Located in brush border membrane. Orthologous to human SLC5A6 (solute carrier family 5 member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 226.9), Adrenal (RPKM 189.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc5a6 in Genome Data Viewer
Location:
6q14
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31039865..31051671)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25319187..25331713)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26685823..26697110)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene all-trans retinoic acid-induced differentiation factor Neighboring gene transcription factor 23 Neighboring gene proline rich 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat. Nabokina SM, et al. Am J Physiol Renal Physiol, 2003 Apr. PMID 12620923
  2. Molecular characterization of the 5' regulatory region of rat sodium-dependent multivitamin transporter gene. Chatterjee NS, et al. Am J Physiol Cell Physiol, 2001 Mar. PMID 11171574
  3. Molecular mechanism of the intestinal biotin transport process. Chatterjee NS, et al. Am J Physiol, 1999 Oct. PMID 10516089
  4. Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells. Uchida Y, et al. J Neurochem, 2015 Jul. PMID 25809983
  5. Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption. Ghosal A, et al. Am J Physiol Gastrointest Liver Physiol, 2013 Jan 1. PMID 23104561, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of SMVT is developmentally regulated in jejunal epithelial brush border membranes
    Title: Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables biotin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables biotin transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iodide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables iodide transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables monoatomic ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables monocarboxylate:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables pantothenate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables pantothenate:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-dependent multivitamin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium-dependent multivitamin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium-dependent multivitamin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfur compound transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables vitamin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biotin import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in biotin import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biotin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biotin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biotin transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in biotin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in inorganic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in iodide transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in iodide transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pantothenate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pantothenate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pantothenate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-dependent multivitamin transporter
Names
Na(+)-dependent multivitamin transporter
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001434151.1 → NP_001421080.1  sodium-dependent multivitamin transporter

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  2. NM_001434152.1 → NP_001421081.1  sodium-dependent multivitamin transporter

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001434153.1 → NP_001421082.1  sodium-dependent multivitamin transporter

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  4. NM_130746.2 → NP_570102.1  sodium-dependent multivitamin transporter

    See identical proteins and their annotated locations for NP_570102.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    O70247
    UniProtKB/TrEMBL
    A0A8L2R3T7, B4F760
    Conserved Domains (1) summary
    cl00456
    Location:23 → 548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    31039865..31051671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111708.2 → XP_038967636.1  sodium-dependent multivitamin transporter isoform X1

    UniProtKB/Swiss-Prot
    O70247
    UniProtKB/TrEMBL
    A0A8L2R3T7, B4F760
    Related
    ENSRNOP00000075361.1, ENSRNOT00000082623.3
    Conserved Domains (1) summary
    cl00456
    Location:23 → 548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_039111710.2 → XP_038967638.1  sodium-dependent multivitamin transporter isoform X1

    UniProtKB/Swiss-Prot
    O70247
    UniProtKB/TrEMBL
    A0A8L2R3T7, B4F760
    Conserved Domains (1) summary
    cl00456
    Location:23 → 548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_039111709.2 → XP_038967637.1  sodium-dependent multivitamin transporter isoform X1

    UniProtKB/Swiss-Prot
    O70247
    UniProtKB/TrEMBL
    A0A8L2R3T7, B4F760
    Conserved Domains (1) summary
    cl00456
    Location:23 → 548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70247.1 GenPept UniProtKB/Swiss-Prot:O70247

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