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Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 [ Mus musculus (house mouse) ]

Gene ID: 16497, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnab1provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, beta member 1provided by MGI
Primary source
MGI:MGI:109155
See related
Ensembl:ENSMUSG00000027827 AllianceGenome:MGI:109155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akr8a8; Kvbeta1.1; mKv(beta)1
Summary
Predicted to enable several functions, including NADPH binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Acts upstream of or within learning or memory and regulation of potassium ion transmembrane transporter activity. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and perikaryon. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in juxtaparanode region of axon. Is expressed in brain; heart; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 15.7), cortex adult (RPKM 8.2) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnab1 in Genome Data Viewer
Location:
3 E1; 3 30.15 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (64856636..65285643)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (64949212..65378225)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 13 Neighboring gene predicted gene, 25222 Neighboring gene STARR-seq mESC enhancer starr_07851 Neighboring gene predicted gene, 54196 Neighboring gene STARR-seq mESC enhancer starr_07852 Neighboring gene STARR-seq mESC enhancer starr_07853 Neighboring gene RIKEN cDNA A330015K06 gene Neighboring gene STARR-seq mESC enhancer starr_07854 Neighboring gene RIKEN cDNA A730090N16 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:65123524-65123825 Neighboring gene STARR-positive B cell enhancer ABC_E517 Neighboring gene acyl-CoA synthetase family member 2 pseudogene Neighboring gene signal sequence receptor, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice. Murphy GG, et al. Curr Biol, 2004 Nov 9. PMID 15530391
  2. Mouse brain potassium channel beta1 subunit mRNA: cloning and distribution during development. Butler DM, et al. J Neurobiol, 1998 Feb 5. PMID 9468385
  3. Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Giese KP, et al. Learn Mem, 1998 Sep-Oct. PMID 10454353, Free PMC Article
  4. Ion channel proteins in mouse and human vestibular tissue. Hotchkiss K, et al. Otolaryngol Head Neck Surg, 2005 Jun. PMID 15944564
  5. Learning and memory impairments in Kv beta 1.1-null mutants are rescued by environmental enrichment or ageing. Need AC, et al. Eur J Neurosci, 2003 Sep. PMID 14511342

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins.
    Title: Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
  2. Data, including data from studies in knockout mice, suggest that association/disassociation of subunits Kcnma1 and Kcnab1 of the BK channel (large-conductance calcium-activated potassium channel) is involved in function of coronary artery smooth muscle cells and their dysfunction during ischemia/reperfusion-induced myocardial injury in diabetes.
    Title: Coronary arterial BK channel dysfunction exacerbates ischemia/reperfusion-induced myocardial injury in diabetic mice.
  3. Kvbeta1 differentially regulates the functional cell surface expression of myocardial I(to,f) and I(K,slow2) channels.
    Title: Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alcohol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aldo-keto reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldo-keto reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldo-keto reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carbonyl reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of potassium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in juxtaparanode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in proximal dendrite ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IC
Inferred by Curator
more info
 PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
voltage-gated potassium channel subunit beta-1
Names
K(+) channel subunit beta-1
voltage dependent potassium channel subunit beta-1
NP_001276379.1
NP_001344287.1
NP_001390801.1
NP_034727.3
XP_006501120.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289450.2 → NP_001276379.1  voltage-gated potassium channel subunit beta-1 isoform 2

    See identical proteins and their annotated locations for NP_001276379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC113279, AC119855, AC134550
    UniProtKB/TrEMBL
    Q3U6C5, Q9D5E9
    Related
    ENSMUST00000161404.8
    Conserved Domains (1) summary
    cl00470
    Location:1 → 287
    AKR_SF; Aldo-keto reductase (AKR) superfamily

  2. NM_001357358.2 → NP_001344287.1  voltage-gated potassium channel subunit beta-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113279, AC113458, AC134550
    Consensus CDS
    CCDS89632.1
    UniProtKB/TrEMBL
    A0A5F8MPK0
    Related
    ENSMUSP00000159000.2, ENSMUST00000238901.2
    Conserved Domains (1) summary
    TIGR01293
    Location:91 → 407
    Kv_beta; voltage-dependent potassium channel beta subunit, animal

  3. NM_001403872.1 → NP_001390801.1  voltage-gated potassium channel subunit beta-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113458, AC134550
    UniProtKB/TrEMBL
    Q8CD65
    Related
    ENSMUST00000159525.8

  4. NM_010597.6 → NP_034727.3  voltage-gated potassium channel subunit beta-1 isoform 1

    See identical proteins and their annotated locations for NP_034727.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC113279, AC113458, AC134550
    Consensus CDS
    CCDS38447.1
    UniProtKB/Swiss-Prot
    P63143, P97380, Q61763, Q63277, Q91WM5
    UniProtKB/TrEMBL
    Q9D5E9
    Related
    ENSMUSP00000047480.9, ENSMUST00000049230.11
    Conserved Domains (1) summary
    cd19159
    Location:71 → 393
    AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    64856636..65285643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501057.1 → XP_006501120.1  voltage-gated potassium channel subunit beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MPA4, Q9D5E9
    Related
    ENSMUSP00000158882.2, ENSMUST00000239069.2
    Conserved Domains (1) summary
    cd19159
    Location:78 → 400
    AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63143.2 GenPept UniProtKB/Swiss-Prot:P63143

Gene LinkOut

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