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DBN1 drebrin 1 [ Homo sapiens (human) ]

Gene ID: 1627, updated on 3-Nov-2024

Summary

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Official Symbol
DBN1provided by HGNC
Official Full Name
drebrin 1provided by HGNC
Primary source
HGNC:HGNC:2695
See related
Ensembl:ENSG00000113758 MIM:126660; AllianceGenome:HGNC:2695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D0S117E
Summary
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 21.1), brain (RPKM 16.5) and 24 other tissues See more
Orthologs
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Genomic context

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See DBN1 in Genome Data Viewer
Location:
5q35.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177456610..177473634, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177999656..178023769, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176883611..176900635, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176853351-176853890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23719 Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176867639-176868335 Neighboring gene PRR7 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176874472-176875100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176876138-176876638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176876639-176877139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16688 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176881361-176882061 Neighboring gene Sharpr-MPRA regulatory region 1974 Neighboring gene proline rich 7, synaptic Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176884168-176884868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176894101-176894646 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176895193-176895738 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176895739-176896284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176897377-176897922 Neighboring gene hESC enhancers GRCh37_chr5:176899493-176899996 and GRCh37_chr5:176899997-176900498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176904724-176905224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176911017-176911732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176911733-176912448 Neighboring gene PDZ and LIM domain 7 Neighboring gene Sharpr-MPRA regulatory region 15492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176918835-176919378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176919379-176919920 Neighboring gene Sharpr-MPRA regulatory region 583 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176923257-176923998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176925479-176926218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176929555-176930508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176930509-176931460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23727 Neighboring gene docking protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of drebrin, an actin binding protein, in basal cell carcinoma, trichoblastoma and trichoepithelioma. Mizutani Y, et al. Histol Histopathol, 2014 Jun. PMID 24346822
  2. Effects of neuronal drebrin on actin dynamics. Grintsevich EE. Biochem Soc Trans, 2021 Apr 30. PMID 33739391
  3. Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis. Dombroski TCD, et al. Epilepsia, 2020 Aug. PMID 32662890
  4. Downregulation of DBN1 is related to vincristine resistance in colon cancer cells. Han Z, et al. J Cancer Res Ther, 2019 Jan-Mar. PMID 30880752
  5. The Role of Drebrin in Cancer Cell Invasion. Dart AE, et al. Adv Exp Med Biol, 2017. PMID 28865033

See all (213) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis.
    Title: The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis.
  2. Drebrin promotes lung adenocarcinoma cell migration through inducing integrin beta1 endocytosis.
    Title: Drebrin promotes lung adenocarcinoma cell migration through inducing integrin β1 endocytosis.
  3. Effects of neuronal drebrin on actin dynamics.
    Title: Effects of neuronal drebrin on actin dynamics.
  4. Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia.
    Title: Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia.
  5. Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis.
    Title: Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis.
  6. TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
    Title: TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma.
  7. we show that drebrin and hCDC14A regulate the recruitment of the actin organizer Arp2 to centrosomes. In addition, during ciliogenesis hCDC14A also regulates endocytosis and targeting of myosin Va vesicles to the basal body in a drebrin-independent manner, indicating that it impacts primary cilia formation in a multilayered manner.
    Title: The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.
  8. Study results showed that the vincristine resistant colon cancer cell line has reduced DBN1 expression which may be related to changes in the drug-target sites.
    Title: Downregulation of DBN1 is related to vincristine resistance in colon cancer cells.
  9. Drebrin may regulate activities of epigenetic reader ZMYND8 via its cytoplasmic sequestration.
    Title: The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin.
  10. Inhibition of cortactin or dynamin-2 abrogated the increased virus entry observed in DBN1-deficient cells, suggesting that DBN1 suppresses dynamin-mediated endocytosis via interaction with cortactin.
    Title: Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Overexpression of the N-terminal region of drebrin inhibits HIV-1 Env-induced membrane fusion. Downregulation of drebrin expression by siRNA increases HIV-1 syncytia formation and viral entry PubMed
env Drebrin interacts and co-localizes with CD4 and CXCR4 during HIV-1 infection of CD4+ T cells in an Env-dependent manner PubMed
env Accumulation of drebrin at Env-induced capping areas and Env-induced cellular contacts, but not at unspecific cell to cell contacts, illustrates the specificity of drebrin recruiment by HIV-1 Env PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with drebrin in HIV-1-infected CD4+ T cells PubMed
Tat tat Drebrin 1 (DBN1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat Expression of HIV-1 Tat downregulates the abundance of drebrin 1 (DBN1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434D064

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables profilin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell communication by chemical coupling IEA
Inferred from Electronic Annotation
more info
  
involved_in cell communication by electrical coupling IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic sequestering of protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic sequestering of protein IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in generation of neurons IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of protein location in cell IEA
Inferred from Electronic Annotation
more info
  
involved_in neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of receptor localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendrite development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of neuronal synaptic plasticity NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in actomyosin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cortical cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite NAS
Non-traceable Author Statement
more info
 PubMed 
located_in gap junction IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
drebrin
Names
developmentally-regulated brain protein
drebrin A
drebrin E
drebrin E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363541.2 → NP_001350470.2  drebrin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini and is longer compared to isoform a.
    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS87354.1
    UniProtKB/TrEMBL
    A0A2Z6ATB6
    Related
    ENSP00000377195.1, ENST00000393565.6
    Conserved Domains (2) summary
    cd11281
    Location:4 → 139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    PHA03247
    Location:277 → 606
    PHA03247; large tegument protein UL36; Provisional

  2. NM_001364151.2 → NP_001351080.2  drebrin isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction and contains an alternate in-frame exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini and is longer compared to isoform a. Variant 4 encodes the longest isoform (d).
    Source sequence(s)
    AC145098
    UniProtKB/TrEMBL
    A0A2Z6ATB6
    Conserved Domains (2) summary
    cd11281
    Location:4 → 138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    PHA03247
    Location:276 → 605
    PHA03247; large tegument protein UL36; Provisional

  3. NM_001364152.2 → NP_001351081.2  drebrin isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC145098
    UniProtKB/TrEMBL
    B7Z2Z0

  4. NM_001393630.1 → NP_001380559.1  drebrin isoform f

    Status: REVIEWED

    Source sequence(s)
    AC145098
    UniProtKB/TrEMBL
    A0A2Z6ATB6
    Conserved Domains (1) summary
    cd11281
    Location:32 → 141
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

  5. NM_001393631.1 → NP_001380560.1  drebrin isoform g

    Status: REVIEWED

    Source sequence(s)
    AC145098
    UniProtKB/TrEMBL
    A0A2Z6ATB6
    Conserved Domains (1) summary
    cl15697
    Location:1 → 76
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  6. NM_004395.4 → NP_004386.3  drebrin isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (a).
    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS4420.1
    UniProtKB/Swiss-Prot
    A8MV58, B2RBG0, Q16643, Q9UFZ5
    UniProtKB/TrEMBL
    A0A2Z6ATB6
    Related
    ENSP00000308532.5, ENST00000309007.9
    Conserved Domains (2) summary
    cd11281
    Location:4 → 139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    PHA03247
    Location:277 → 565
    PHA03247; large tegument protein UL36; Provisional

  7. NM_080881.3 → NP_543157.2  drebrin isoform b

    Status: REVIEWED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS4421.1
    UniProtKB/TrEMBL
    A0A2Z6ATB6
    Related
    ENSP00000292385.5, ENST00000292385.9
    Conserved Domains (2) summary
    cd11281
    Location:32 → 141
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    PHA03247
    Location:279 → 567
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    177456610..177473634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416833.1 → XP_047272789.1  drebrin isoform X2

  2. XM_017009139.2 → XP_016864628.1  drebrin isoform X1

    UniProtKB/TrEMBL
    A0A2Z6ATB6
    Conserved Domains (1) summary
    cd11281
    Location:32 → 141
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177999656..178023769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351859.1 → XP_054207834.1  drebrin isoform X4

  2. XM_054351858.1 → XP_054207833.1  drebrin isoform X3

  3. XM_054351860.1 → XP_054207835.1  drebrin isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16643.4 GenPept UniProtKB/Swiss-Prot:Q16643

Gene LinkOut

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