U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR155 G protein-coupled receptor 155 [ Homo sapiens (human) ]

Gene ID: 151556, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
GPR155provided by HGNC
Official Full Name
G protein-coupled receptor 155provided by HGNC
Primary source
HGNC:HGNC:22951
See related
Ensembl:ENSG00000163328 MIM:620855; AllianceGenome:HGNC:22951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEP.7; PGR22; DEPDC3; LYCHOS
Summary
Enables cholesterol binding activity. Involved in several processes, including cellular response to amino acid starvation; cellular response to cholesterol; and positive regulation of TORC1 signaling. Located in extracellular exosome. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in stomach (RPKM 11.2), brain (RPKM 8.6) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GPR155 in Genome Data Viewer
Location:
2q31.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (174431571..174487029, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (174920213..174975693, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175296299..175351757, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene corepressor interacting with RBPJ, CIR1 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175256788-175256952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:175260886-175261386 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:175274337-175274938 Neighboring gene secernin 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175351272-175351454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16774 Neighboring gene GPR155 divergent transcript Neighboring gene RPA3 pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1. Shin HR, et al. Science, 2022 Sep 16. PMID 36007018, Free PMC Article
  2. Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma. Umeda S, et al. BMC Cancer, 2017 Sep 1. PMID 28863781, Free PMC Article
  3. GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer. Shimizu D, et al. Sci Rep, 2017 Feb 6. PMID 28165032, Free PMC Article
  4. Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p. Liu L, et al. Pathol Res Pract, 2024 May. PMID 38678850
  5. Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Nishimura Y, et al. Hum Mol Genet, 2007 Jul 15. PMID 17519220

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p.
    Title: Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p.
  2. Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
    Title: Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
  3. GPR155 may represent a biomarker for diagnosing and predicting hematogenous metastasis of gastric cancer.
    Title: GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer.
  4. Downregulation of GPR155 may serve as a prognosticator that also predicts initial recurrence sites independent of hepatitis virus infection.
    Title: Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ31819, FLJ39346

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to cholesterol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
lysosomal cholesterol signaling protein
Names
G-protein coupled receptor PGR22
integral membrane protein GPR155

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033045.4 → NP_001028217.1  lysosomal cholesterol signaling protein isoform 1

    See identical proteins and their annotated locations for NP_001028217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    AC018470, AK056381, AL834154
    Consensus CDS
    CCDS2259.1
    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
    Related
    ENSP00000295500.4, ENST00000295500.8
    Conserved Domains (2) summary
    cd04443
    Location:751 → 833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38 → 366
    Mem_trans; Membrane transport protein

  2. NM_001267050.2 → NP_001253979.1  lysosomal cholesterol signaling protein isoform 1

    See identical proteins and their annotated locations for NP_001253979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC018470, BC035037
    Consensus CDS
    CCDS2259.1
    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
    Related
    ENSP00000376334.2, ENST00000392551.6
    Conserved Domains (2) summary
    cd04443
    Location:751 → 833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38 → 366
    Mem_trans; Membrane transport protein

  3. NM_001267051.2 → NP_001253980.1  lysosomal cholesterol signaling protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC018470, AK056381, BC036681, DC334438
    Consensus CDS
    CCDS74605.1
    UniProtKB/TrEMBL
    A0A087WXK4
    Related
    ENSP00000481104.1, ENST00000614352.4
    Conserved Domains (2) summary
    cd04443
    Location:723 → 805
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38 → 366
    Mem_trans; Membrane transport protein

  4. NM_152529.7 → NP_689742.4  lysosomal cholesterol signaling protein isoform 1

    See identical proteins and their annotated locations for NP_689742.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC018470, AK315125
    Consensus CDS
    CCDS2259.1
    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
    Related
    ENSP00000376335.2, ENST00000392552.7
    Conserved Domains (2) summary
    cd04443
    Location:751 → 833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38 → 366
    Mem_trans; Membrane transport protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    174431571..174487029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003487.2 → XP_016858976.1  lysosomal cholesterol signaling protein isoform X1

    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
    Conserved Domains (2) summary
    cd04443
    Location:751 → 833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38 → 366
    Mem_trans; Membrane transport protein

  2. XM_017003485.3 → XP_016858974.1  lysosomal cholesterol signaling protein isoform X1

    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
    Conserved Domains (2) summary
    cd04443
    Location:751 → 833
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:38 → 366
    Mem_trans; Membrane transport protein

  3. XM_047443532.1 → XP_047299488.1  lysosomal cholesterol signaling protein isoform X1

    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    174920213..174975693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340820.1 → XP_054196795.1  lysosomal cholesterol signaling protein isoform X1

    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6

  2. XM_054340818.1 → XP_054196793.1  lysosomal cholesterol signaling protein isoform X1

    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6

  3. XM_054340819.1 → XP_054196794.1  lysosomal cholesterol signaling protein isoform X1

    UniProtKB/Swiss-Prot
    B2RCI2, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q7Z3F1, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z3F1.2 GenPept UniProtKB/Swiss-Prot:Q7Z3F1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools