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GPBAR1 G protein-coupled bile acid receptor 1 [ Homo sapiens (human) ]

Gene ID: 151306, updated on 12-Nov-2024

Summary

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Official Symbol
GPBAR1provided by HGNC
Official Full Name
G protein-coupled bile acid receptor 1provided by HGNC
Primary source
HGNC:HGNC:19680
See related
Ensembl:ENSG00000179921 MIM:610147; AllianceGenome:HGNC:19680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BG37; TGR5; M-BAR; GPCR19; GPR131
Summary
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in gall bladder (RPKM 4.9), fat (RPKM 2.9) and 11 other tissues See more
Orthologs
mouse all
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Genomic context

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See GPBAR1 in Genome Data Viewer
Location:
2q35
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218259496..218263861)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218745197..218749562)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219124219..219128584)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928487 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:219081921-219082524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12312 Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene tRNA-Tyr (anticodon ATA) 1-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219126185-219126990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219133153-219134038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17118 Neighboring gene angio associated migratory cell protein Neighboring gene PNKD metallo-beta-lactamase domain containing Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene microRNA 6513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes.
    Title: Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes.
  2. Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5.
    Title: Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5.
  3. Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute cholestatic liver injury via antagonizing NLRP3-ASC inflammasome.
    Title: Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute cholestatic liver injury via antagonizing NLRP3-ASC inflammasome.
  4. TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing.
    Title: TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing.
  5. The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome.
    Title: The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome.
  6. Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO.
    Title: Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO.
  7. Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
    Title: Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
  8. GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients.
    Title: GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients.
  9. Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling.
    Title: Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling.
  10. Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
    Title: Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Submit: New GeneRIF Correction See all GeneRIFs (91)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40597

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled bile acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled bile acid receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled bile acid receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to bile acid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cholangiocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled bile acid receptor 1
Names
G-protein coupled bile acid receptor BG37
G-protein coupled receptor GPCR19
membrane bile acid receptor
membrane-type receptor for bile acids

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077191.2 → NP_001070659.1  G-protein coupled bile acid receptor 1

    See identical proteins and their annotated locations for NP_001070659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC021016, AK122660, BC033625
    Consensus CDS
    CCDS46515.1
    UniProtKB/Swiss-Prot
    B3KV35, Q8TDU6
    Related
    ENSP00000430886.1, ENST00000522678.5
    Conserved Domains (2) summary
    cd14964
    Location:49 → 75
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:28 → 284
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001077194.2 → NP_001070662.1  G-protein coupled bile acid receptor 1

    See identical proteins and their annotated locations for NP_001070662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC021016, AK122660, BC033625, BI834364
    Consensus CDS
    CCDS46515.1
    UniProtKB/Swiss-Prot
    B3KV35, Q8TDU6
    Related
    ENSP00000428824.1, ENST00000521462.1
    Conserved Domains (2) summary
    cd14964
    Location:49 → 75
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:28 → 284
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001321950.2 → NP_001308879.1  G-protein coupled bile acid receptor 1

    Status: REVIEWED

    Source sequence(s)
    AC021016, AK122658, BC033625
    Consensus CDS
    CCDS46515.1
    UniProtKB/Swiss-Prot
    B3KV35, Q8TDU6
    Related
    ENSP00000430698.1, ENST00000479077.5
    Conserved Domains (2) summary
    cd14964
    Location:49 → 75
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:28 → 284
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. NM_170699.3 → NP_733800.1  G-protein coupled bile acid receptor 1

    See identical proteins and their annotated locations for NP_733800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC021016, AK122660, BC033625
    Consensus CDS
    CCDS46515.1
    UniProtKB/Swiss-Prot
    B3KV35, Q8TDU6
    Related
    ENSP00000430202.1, ENST00000519574.2
    Conserved Domains (2) summary
    cd14964
    Location:49 → 75
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:28 → 284
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    218259496..218263861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510743.1 → XP_011509045.1  G-protein coupled bile acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011509045.1

    UniProtKB/Swiss-Prot
    B3KV35, Q8TDU6
    Conserved Domains (2) summary
    cd14964
    Location:49 → 75
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:28 → 284
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    218745197..218749562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340779.1 → XP_054196754.1  G-protein coupled bile acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B3KV35, Q8TDU6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TDU6.1 GenPept UniProtKB/Swiss-Prot:Q8TDU6

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