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H2-Q2 histocompatibility 2, Q region locus 2 [ Mus musculus (house mouse) ]

Gene ID: 15013, updated on 2-Nov-2024

Summary

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Official Symbol
H2-Q2provided by MGI
Official Full Name
histocompatibility 2, Q region locus 2provided by MGI
Primary source
MGI:MGI:95931
See related
Ensembl:ENSMUSG00000091705 AllianceGenome:MGI:95931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2Q2; H2-D1; H2-K1; gs14-2; Gm11132
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Acts upstream of or within female pregnancy. Predicted to be located in several cellular components, including Golgi apparatus; bounding membrane of organelle; and endoplasmic reticulum exit site. Predicted to be part of MHC class I peptide loading complex; MHC class I protein complex; and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in small intestine adult (RPKM 179.7), duodenum adult (RPKM 165.2) and 3 other tissues See more
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Genomic context

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See H2-Q2 in Genome Data Viewer
Location:
17 B1; 17 18.64 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35561283..35565740)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35342307..35346764)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, Q region locus 1 Neighboring gene Nhp2 non-histone chromosome protein 2-like 1 pseudogene Neighboring gene predicted gene, 52319 Neighboring gene histocompatibility 2, Q region locus 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Embryonal carcinoma cells express Qa and Tla class I genes of the major histocompatibility complex. Ostrand-Rosenberg S, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2740345, Free PMC Article
  2. Preferential survival of mice expressing the Qa-2 antigen. Warner CM, et al. J Reprod Fertil, 1993 Sep. PMID 8283431
  3. Identification of a recombinogenic major histocompatibility complex Q gene with diverse alleles. Cullen MK, et al. J Exp Med, 1993 Jun 1. PMID 8496692, Free PMC Article
  4. DNA sequences of mouse H-2 and Qa genes. Kuhner MK, et al. Immunogenetics, 1989. PMID 2592022
  5. Three spontaneous H-2Db mutants are generated by genetic micro-recombination (gene conversion) events. Impact on the H-2-restricted immune responsiveness. Hemmi S, et al. J Exp Med, 1988 Dec 1. PMID 3199070, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP complex binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within female pregnancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histocompatibility 2, Q region locus 2
Names
MHC class II antigen D
MHC class II antigen K
MHC classIb like protein GS14-2
class Ib major histocompatibility complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368740.1 → NP_001355669.1  histocompatibility 2, Q region locus 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974466
    UniProtKB/TrEMBL
    Q2XN57
    Conserved Domains (2) summary
    cd07698
    Location:204 → 296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:23 → 200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. NM_010392.3 → NP_034522.2  histocompatibility 2, Q region locus 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034522.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CR974466
    Consensus CDS
    CCDS28696.1
    UniProtKB/TrEMBL
    Q2XN57, Q4KN81
    Related
    ENSMUSP00000078138.6, ENSMUST00000074806.12
    Conserved Domains (3) summary
    cd07698
    Location:204 → 296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:22 → 200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:334 → 357
    MHC_I_C; MHC_I C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35561283..35565740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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