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Cdk5 cyclin-dependent kinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140908, updated on 14-Nov-2024

Summary

Official Symbol
Cdk5provided by RGD
Official Full Name
cyclin-dependent kinase 5provided by RGD
Primary source
RGD:70514
See related
EnsemblRapid:ENSRNOG00000008017 AllianceGenome:RGD:70514
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including ephrin receptor binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Acts upstream of or within protein phosphorylation. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Used to study brain ischemia; depressive disorder; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 242.9), Adrenal (RPKM 102.7) and 9 other tissues See more
Orthologs
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Genomic context

See Cdk5 in Genome Data Viewer
Location:
4q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11647098..11651606)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10754682..10760110)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7282945..7287427)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Fas-activated serine/threonine kinase Neighboring gene solute carrier family 4 member 2 Neighboring gene acid sensing ion channel subunit 3 Neighboring gene ATP binding cassette subfamily B member 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ErbB-2 class receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables ErbB-2 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ErbB-2 class receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ErbB-3 class receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables ErbB-3 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ErbB-3 class receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetylcholine receptor activator activity IEA
Inferred from Electronic Annotation
more info
 
enables acetylcholine receptor activator activity ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine receptor activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables p53 binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables tau-protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Schwann cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Schwann cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within associative learning ISO
Inferred from Sequence Orthology
more info
 
involved_in axon extension TAS
Traceable Author Statement
more info
PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellar cortex development ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellar cortex formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebellar cortex formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellum development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within corpus callosum development ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hippocampus development ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within layer formation in cerebral cortex ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of presynaptic cytosolic calcium concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to synapse IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse pruning EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of synapse pruning IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
involved_in synapse assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within telencephalon development ISO
Inferred from Sequence Orthology
more info
 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction TAS
Traceable Author Statement
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein kinase 5 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein kinase 5 complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein kinase 5 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 5
Names
TPKII catalytic subunit
cell division protein kinase 5
cyclin-dependent-like kinase 5
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit
NP_543161.1
XP_063141514.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080885.2NP_543161.1  cyclin-dependent kinase 5

    See identical proteins and their annotated locations for NP_543161.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q03114
    UniProtKB/TrEMBL
    A0A8L2UIH0, A6K556
    Related
    ENSRNOP00000011052.3, ENSRNOT00000011052.6
    Conserved Domains (1) summary
    cd07839
    Location:3286
    STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    11647098..11651606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285444.1XP_063141514.1  cyclin-dependent kinase 5 isoform X1