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Phkg2 phosphorylase kinase catalytic subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140671, updated on 14-Nov-2024

Summary

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Official Symbol
Phkg2provided by RGD
Official Full Name
phosphorylase kinase catalytic subunit gamma 2provided by RGD
Primary source
RGD:620024
See related
EnsemblRapid:ENSRNOG00000018725 AllianceGenome:RGD:620024
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including ATP binding activity; calmodulin binding activity; and phosphorylase kinase activity. Involved in glycogen metabolic process; positive regulation of glycogen catabolic process; and protein phosphorylation. Part of phosphorylase kinase complex. Used to study glycogen storage disease. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to human PHKG2 (phosphorylase kinase catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 429.0), Thymus (RPKM 117.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Phkg2 in Genome Data Viewer
Location:
1q37
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191614738..191627615)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182184362..182197124)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199019298..199032053)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Snf2-related CREBBP activator protein Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40 Neighboring gene zinc finger protein 629 Neighboring gene 5S ribosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glycogenolysis in liver of phosphorylase kinase-deficient rats during liver perfusion and ischaemia. Lutaya G, et al. Biochem J, 1983 Aug 15. PMID 6615485, Free PMC Article
  2. Molecular cloning and enzymatic analysis of the rat homolog of "PhK-gamma T," an isoform of phosphorylase kinase catalytic subunit. Calalb MB, et al. J Biol Chem, 1992 Jan 25. PMID 1370475
  3. Liver glycogenosis due to phosphorylase kinase deficiency: PHKG2 gene structure and mutations associated with cirrhosis. Burwinkel B, et al. Hum Mol Genet, 1998 Jan. PMID 9384616
  4. Mutations in the testis/liver isoform of the phosphorylase kinase gamma subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat and in humans. Maichele AJ, et al. Nat Genet, 1996 Nov. PMID 8896567
  5. Comparison of glycogen phosphorylase kinases of various rat tissues. Taira T, et al. J Biochem, 1982 Mar. PMID 6281247

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorylase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorylase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorylase kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of phosphorylase kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphorylase kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Names
PHK-gamma-LT
PHK-gamma-T
phosphorylase kinase gamma subunit 2
phosphorylase kinase subunit gamma-2
phosphorylase kinase, gamma 2 (testis)
serine/threonine-protein kinase PHKG2
NP_542151.1
XP_008758077.1
XP_038937387.1
XP_038937457.1
XP_038937492.1
XP_038937593.1
XP_063126562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080584.4 → NP_542151.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform

    See identical proteins and their annotated locations for NP_542151.1

    Status: PROVISIONAL

    Source sequence(s)
    M73808
    UniProtKB/Swiss-Prot
    A1A5L8, P31325
    UniProtKB/TrEMBL
    A6I9R0
    Conserved Domains (1) summary
    cd14181
    Location:13 → 291
    STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191614738..191627615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270492.1 → XP_063126562.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

    UniProtKB/Swiss-Prot
    A1A5L8, P31325

  2. XM_008759855.4 → XP_008758077.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

    See identical proteins and their annotated locations for XP_008758077.1

    UniProtKB/Swiss-Prot
    A1A5L8, P31325
    UniProtKB/TrEMBL
    A6I9R0
    Conserved Domains (1) summary
    cd14181
    Location:13 → 291
    STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

  3. XM_039081459.2 → XP_038937387.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

    UniProtKB/Swiss-Prot
    A1A5L8, P31325
    UniProtKB/TrEMBL
    A6I9R0
    Related
    ENSRNOP00000072734.1, ENSRNOT00000087142.3
    Conserved Domains (1) summary
    cd14181
    Location:13 → 291
    STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

  4. XM_039081665.2 → XP_038937593.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:13 → 267
    PKc_like; Protein Kinases, catalytic domain

  5. XM_039081529.2 → XP_038937457.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

    UniProtKB/Swiss-Prot
    A1A5L8, P31325
    UniProtKB/TrEMBL
    A6I9R0
    Conserved Domains (1) summary
    cd14181
    Location:13 → 291
    STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

  6. XM_039081564.2 → XP_038937492.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

    UniProtKB/TrEMBL
    A6I9R1, A6I9R4
    Conserved Domains (1) summary
    cl21453
    Location:1 → 189
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31325.1 GenPept UniProtKB/Swiss-Prot:P31325

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