Ecm1 extracellular matrix protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ecm1provided by MGI
Official Full Name: extracellular matrix protein 1provided by MGI
Primary source: MGI:MGI:103060
See related: Ensembl:ENSMUSG00000028108 AllianceGenome:MGI:103060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p85
Summary: Enables interleukin-2 receptor binding activity. Acts upstream of or within several processes, including regulation of bone mineralization; regulation of type 2 immune response; and skeletal system development. Located in extracellular space. Is expressed in several structures, including alimentary system; autopod; bone; cardiovascular system; and skin. Human ortholog(s) of this gene implicated in lipoid proteinosis. Orthologous to human ECM1 (extracellular matrix protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 290.2), bladder adult (RPKM 142.1) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.91 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95641459..95646880, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95734147..95739876, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction.
Title: Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction.
Remodeling of tumor microenvironment by extracellular matrix protein 1a differentially regulates ovarian cancer metastasis.
Title: Remodeling of tumor microenvironment by extracellular matrix protein 1a differentially regulates ovarian cancer metastasis.
Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions.
Title: Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions.
Downregulation of extracellular matrix protein 1 effectively ameliorates osteoarthritis progression in vivo.
Title: Downregulation of extracellular matrix protein 1 effectively ameliorates osteoarthritis progression in vivo.
Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice.
Title: Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice.
Studied the role of extracellular matrix protein 1 (ECM1) in controlling colonic inflammation through macrophages in inflammatory bowel disease (IBD). Findings show that ECM1 has an important function in promoting M1 macrophage polarization.
Title: ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation.
ECM1, produced by hepatocytes, inhibits activation of TGFB and its activation of hepatic stellate cells to prevent fibrogenesis in mouse liver.
Title: ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice.
findings suggest ECM1 is released from infiltrating inflammatory cells, which leads to cardiac fibroblast stimulation and fibrosis in aging and myocardial infarction. ECM1 may be a novel intermediary between inflammation and fibrosis.
Title: Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction.
data identify ECM1 as a soluble protein to promote TFH cell differentiation and antibody production.
Title: Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production.
ECM1 seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 rescues disorganized growth plates of PTHrP-null mice; ECM1 and progranulin chondrogenic growth factor constitute an interaction network.
Title: Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Umi25 (e-PCR), detects polymorphism
- UniSTS:281103

Ecm1 (e-PCR), detects polymorphism
- UniSTS:256887

Ecm1 (e-PCR), detects polymorphism
- UniSTS:502657

AI429208 (e-PCR)
- UniSTS:159142

AI663821 (e-PCR)
- UniSTS:185548

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables interleukin-2 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral bone growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: extracellular matrix protein 1

Names: secretory component p85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252653.4 → NP_001239582.1 extracellular matrix protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

MG954306

Consensus CDS

CCDS57237.1

UniProtKB/TrEMBL

F8WI14, Q3TXB7

Related

ENSMUSP00000029753.7, ENSMUST00000029753.14

Conserved Domains (1) summary

pfam05782
Location:21 → 558

ECM1; Extracellular matrix protein 1 (ECM1)
NM_001355070.3 → NP_001341999.1 extracellular matrix protein 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

MG954306

UniProtKB/TrEMBL

B7ZNR0

Conserved Domains (1) summary

pfam05782
Location:21 → 558

ECM1; Extracellular matrix protein 1 (ECM1)
NM_001409917.1 → NP_001396846.1 extracellular matrix protein 1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409919.1 → NP_001396848.1 extracellular matrix protein 1 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409920.1 → NP_001396849.1 extracellular matrix protein 1 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409921.1 → NP_001396850.1 extracellular matrix protein 1 isoform 7 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409922.1 → NP_001396851.1 extracellular matrix protein 1 isoform 8 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409923.1 → NP_001396852.1 extracellular matrix protein 1 isoform 9 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409924.1 → NP_001396853.1 extracellular matrix protein 1 isoform 10 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409925.1 → NP_001396854.1 extracellular matrix protein 1 isoform 11 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409926.1 → NP_001396855.1 extracellular matrix protein 1 isoform 12 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409927.1 → NP_001396856.1 extracellular matrix protein 1 isoform 13 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409928.1 → NP_001396857.1 extracellular matrix protein 1 isoform 14 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409929.1 → NP_001396858.1 extracellular matrix protein 1 isoform 15 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409930.1 → NP_001396859.1 extracellular matrix protein 1 isoform 16 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409931.1 → NP_001396860.1 extracellular matrix protein 1 isoform 17 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409932.1 → NP_001396861.1 extracellular matrix protein 1 isoform 18 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409933.1 → NP_001396862.1 extracellular matrix protein 1 isoform 19 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409935.1 → NP_001396864.1 extracellular matrix protein 1 isoform 20 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409936.1 → NP_001396865.1 extracellular matrix protein 1 isoform 21 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409938.1 → NP_001396867.1 extracellular matrix protein 1 isoform 22 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409939.1 → NP_001396868.1 extracellular matrix protein 1 isoform 23 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409940.1 → NP_001396869.1 extracellular matrix protein 1 isoform 24 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409941.1 → NP_001396870.1 extracellular matrix protein 1 isoform 25 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409942.1 → NP_001396871.1 extracellular matrix protein 1 isoform 26 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409943.1 → NP_001396872.1 extracellular matrix protein 1 isoform 27 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409944.1 → NP_001396873.1 extracellular matrix protein 1 isoform 28 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409945.1 → NP_001396874.1 extracellular matrix protein 1 isoform 29 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409946.1 → NP_001396875.1 extracellular matrix protein 1 isoform 30 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409947.1 → NP_001396876.1 extracellular matrix protein 1 isoform 31 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409948.1 → NP_001396877.1 extracellular matrix protein 1 isoform 32 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409949.1 → NP_001396878.1 extracellular matrix protein 1 isoform 33 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409950.1 → NP_001396879.1 extracellular matrix protein 1 isoform 34 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409951.1 → NP_001396880.1 extracellular matrix protein 1 isoform 35 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_001409952.1 → NP_001396881.1 extracellular matrix protein 1 isoform 36 precursor

Status: VALIDATED

Source sequence(s)

MG954306
NM_007899.5 → NP_031925.2 extracellular matrix protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_031925.2

Status: VALIDATED

Source sequence(s)

MG954306

Consensus CDS

CCDS17619.1

UniProtKB/Swiss-Prot

Q3U5Q5, Q61508

UniProtKB/TrEMBL

Q3TDX7

Related

ENSMUSP00000112665.3, ENSMUST00000117507.10

Conserved Domains (1) summary

pfam05782
Location:21 → 559

ECM1; Extracellular matrix protein 1 (ECM1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

95641459..95646880 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319450.3 → XP_017174939.1 extracellular matrix protein 1 isoform X6

UniProtKB/TrEMBL

A0A8T9ITP3, Q9Z2R8

Conserved Domains (1) summary

pfam05782
Location:21 → 452

ECM1; Extracellular matrix protein 1 (ECM1)
XM_011240008.4 → XP_011238310.1 extracellular matrix protein 1 isoform X2

UniProtKB/TrEMBL

Q3TXB7

Conserved Domains (1) summary

pfam05782
Location:21 → 576

ECM1; Extracellular matrix protein 1 (ECM1)