Cr2 complement receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cr2provided by MGI
Official Full Name: complement receptor 2provided by MGI
Primary source: MGI:MGI:88489
See related: Ensembl:ENSMUSG00000026616 AllianceGenome:MGI:88489
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cr1; C3DR; CD21; CD35; Cr-1; Cr-2
Summary: Enables complement receptor activity. Acts upstream of or within with a negative effect on complement activation, alternative pathway. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in external side of plasma membrane. Is expressed in several structures, including brain; hemolymphoid system; liver; placenta; and yolk sac. Human ortholog(s) of this gene implicated in common variable immunodeficiency 7; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 7.1), mammary gland adult (RPKM 1.4) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 98.44 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (194819120..194859096, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (195136811..195176880, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study uncovers a damaging effect of complement C3 or downstream complement activation in glaucoma, and it establishes AAV2.CR2-Crry as a viable therapeutic strategy to target pathogenic C3-mediated complement activation in the glaucomatous retina
Title: Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.
These results demonstrate that local expression of Cr2 in the central nervous system is part of the axotomy reaction and is suggested to modulate subsequent complement mediated effects.
Title: Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response.
Immunization of Cr1KO mice with a T cell-dependent antigen resulted in the normal initial expansion of B cells with a germinal center phenotype however these cells were preferentially lost in the Cr1KO animal over time (days).
Title: Murine complement receptor 1 is required for germinal center B cell maintenance but not initiation.
This study demonistrated that receptors for complement C3 fragments (CR2/CR1) may represent a promising future approach for therapeutic immunomodulation after traumatic brain injury.
Title: Deficiency of complement receptors CR2/CR1 in Cr2⁻/⁻ mice reduces the extent of secondary brain damage after closed head injury.
Data suggest that the Cr2KO mouse thus provides a new model system for the analysis of Cr1 and Cr2 functions in the immune response of the mouse.
Title: Generation of a novel Cr2 gene allele by homologous recombination that abrogates production of Cr2 but is sufficient for expression of Cr1.
Murine B cells predominantly express the Cr2 product from the Cr2 gene, whereas follicular dendritic cells (FDCs) almost exclusively express the Cr1 isoform generated from the Cr2 gene.
Title: Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1.
Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization
Title: Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization.
immune system uses three different CR1/2-mediated effector functions to generate optimal antibody responses
Title: Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytes.
Absence of CD21/35 protects mice from chronic wasting disease.
Title: Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease.
We conclude that Cr2 regulates hippocampal neurogenesis
Title: Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (5)
Targeted (8) 1 citation

General gene information

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Markers

Cr2 (e-PCR), detects polymorphism
- UniSTS:257039

Cr2 (e-PCR), detects polymorphism
- UniSTS:141392

NoName (e-PCR)
- UniSTS:489043

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables complement binding	ISO Inferred from Sequence Orthology more info
enables complement receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated immunity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_negative_effect complement activation, alternative pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunoglobulin mediated immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: complement receptor type 2

Names: complement C3d receptor; complement receptor type 1; expressed in B lymphocytes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368765.1 → NP_001355694.1 complement receptor type 2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC109145, AC139206

Consensus CDS

CCDS87949.1

UniProtKB/TrEMBL

A0A1B0GS59

Conserved Domains (1) summary

PHA02927
Location:10 → 272

PHA02927; secreted complement-binding protein; Provisional
NM_007758.3 → NP_031784.1 complement receptor type 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_031784.1

Status: VALIDATED

Source sequence(s)

AC109145, AC139206

Consensus CDS

CCDS15642.1

UniProtKB/Swiss-Prot

P19070

UniProtKB/TrEMBL

Q9DC83

Related

ENSMUSP00000080938.4, ENSMUST00000082321.9

Conserved Domains (2) summary

PHA02639
Location:17 → 211

PHA02639; EEV host range protein; Provisional

PHA02927
Location:172 → 407

PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

194819120..194859096 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497225.4 → XP_006497288.1 complement receptor type 2 isoform X3

See identical proteins and their annotated locations for XP_006497288.1

UniProtKB/Swiss-Prot

P19070

UniProtKB/TrEMBL

Q9DC83

Conserved Domains (2) summary

PHA02639
Location:17 → 211

PHA02639; EEV host range protein; Provisional

PHA02927
Location:172 → 407

PHA02927; secreted complement-binding protein; Provisional
XM_006497224.4 → XP_006497287.1 complement receptor type 2 isoform X2

UniProtKB/Swiss-Prot

P19070

Conserved Domains (1) summary

PHA02927
Location:293 → 528

PHA02927; secreted complement-binding protein; Provisional
XM_006497222.4 → XP_006497285.1 complement receptor type 2 isoform X1

See identical proteins and their annotated locations for XP_006497285.1

UniProtKB/TrEMBL

A0A1B0GS59

Related

ENSMUSP00000147804.2, ENSMUST00000210219.2

Conserved Domains (1) summary

PHA02927
Location:10 → 272

PHA02927; secreted complement-binding protein; Provisional
XM_017314050.3 → XP_017169539.1 complement receptor type 2 isoform X4

UniProtKB/Swiss-Prot

P19070

Conserved Domains (2) summary

cd00033
Location:3 → 48

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:72 → 307

PHA02927; secreted complement-binding protein; Provisional