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CCDC159 coiled-coil domain containing 159 [ Homo sapiens (human) ]

Gene ID: 126075, updated on 2-Nov-2024

Summary

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Official Symbol
CCDC159provided by HGNC
Official Full Name
coiled-coil domain containing 159provided by HGNC
Primary source
HGNC:HGNC:26996
See related
Ensembl:ENSG00000183401 AllianceGenome:HGNC:26996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in spermatid development. Predicted to be located in sperm head-tail coupling apparatus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 10.3), prostate (RPKM 10.0) and 25 other tissues See more
Orthologs
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Genomic context

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See CCDC159 in Genome Data Viewer
Location:
19p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11346519..11354944)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11473497..11481922)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11457195..11465620)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tetraspanin 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14008 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11456465-11457295 Neighboring gene transmembrane protein 205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11461146-11461646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11467020-11467961 Neighboring gene phospholipid phosphatase related 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14012 Neighboring gene SWIM-type zinc finger 7 associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45351, FLJ79238

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in sperm head-tail coupling apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 159

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080503.3 → NP_001073972.2  coiled-coil domain-containing protein 159

    Status: VALIDATED

    Source sequence(s)
    CA848583, CB241007, DC416232
    Consensus CDS
    CCDS45976.1
    UniProtKB/Swiss-Prot
    B4DEG3, B4DWR8, B4E133, B7ZAM4, P0C7I6
    Related
    ENSP00000402239.1, ENST00000458408.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11346519..11354944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438148.1 → XP_047294104.1  coiled-coil domain-containing protein 159 isoform X5

  2. XM_017026256.3 → XP_016881745.1  coiled-coil domain-containing protein 159 isoform X2

  3. XM_047438146.1 → XP_047294102.1  coiled-coil domain-containing protein 159 isoform X4

  4. XM_011527678.3 → XP_011525980.2  coiled-coil domain-containing protein 159 isoform X7

  5. XM_017026260.3 → XP_016881749.1  coiled-coil domain-containing protein 159 isoform X9

  6. XM_047438147.1 → XP_047294103.1  coiled-coil domain-containing protein 159 isoform X5

  7. XM_047438149.1 → XP_047294105.1  coiled-coil domain-containing protein 159 isoform X5

  8. XM_017026261.3 → XP_016881750.1  coiled-coil domain-containing protein 159 isoform X11

  9. XM_047438150.1 → XP_047294106.1  coiled-coil domain-containing protein 159 isoform X5

  10. XM_017026255.2 → XP_016881744.1  coiled-coil domain-containing protein 159 isoform X1

  11. XM_006722643.2 → XP_006722706.1  coiled-coil domain-containing protein 159 isoform X3

    Conserved Domains (1) summary
    TIGR00618
    Location:35 → 224
    sbcc; exonuclease SbcC

  12. XM_017026258.3 → XP_016881747.1  coiled-coil domain-containing protein 159 isoform X6

  13. XM_017026259.3 → XP_016881748.1  coiled-coil domain-containing protein 159 isoform X8

  14. XM_024451347.2 → XP_024307115.1  coiled-coil domain-containing protein 159 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11473497..11481922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319762.1 → XP_054175737.1  coiled-coil domain-containing protein 159 isoform X5

  2. XM_054319763.1 → XP_054175738.1  coiled-coil domain-containing protein 159 isoform X5

  3. XM_054319770.1 → XP_054175745.1  coiled-coil domain-containing protein 159 isoform X11

  4. XM_054319764.1 → XP_054175739.1  coiled-coil domain-containing protein 159 isoform X5

  5. XM_054319758.1 → XP_054175733.1  coiled-coil domain-containing protein 159 isoform X1

  6. XM_054319760.1 → XP_054175735.1  coiled-coil domain-containing protein 159 isoform X3

  7. XM_054319765.1 → XP_054175740.1  coiled-coil domain-containing protein 159 isoform X6

  8. XM_054319767.1 → XP_054175742.1  coiled-coil domain-containing protein 159 isoform X8

  9. XM_054319769.1 → XP_054175744.1  coiled-coil domain-containing protein 159 isoform X10

  10. XM_054319766.1 → XP_054175741.1  coiled-coil domain-containing protein 159 isoform X7

  11. XM_054319768.1 → XP_054175743.1  coiled-coil domain-containing protein 159 isoform X9

  12. XM_054319759.1 → XP_054175734.1  coiled-coil domain-containing protein 159 isoform X2

  13. XM_054319761.1 → XP_054175736.1  coiled-coil domain-containing protein 159 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7I6.2 GenPept UniProtKB/Swiss-Prot:P0C7I6

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