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Ccnd2 cyclin D2 [ Mus musculus (house mouse) ]

Gene ID: 12444, updated on 2-Nov-2024

Summary

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Official Symbol
Ccnd2provided by MGI
Official Full Name
cyclin D2provided by MGI
Primary source
MGI:MGI:88314
See related
Ensembl:ENSMUSG00000000184 AllianceGenome:MGI:88314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cD2; Vin1; Vin-1; 2600016F06Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and protein kinase binding activity. Acts upstream of or within several processes, including adult locomotory behavior; cellular response to X-ray; and long-term memory. Located in nucleus. Part of cyclin D2-CDK4 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); ductal carcinoma in situ; hepatitis B; and liver cancer (multiple). Orthologous to human CCND2 (cyclin D2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 77.3), limb E14.5 (RPKM 41.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Ccnd2 in Genome Data Viewer
Location:
6 F3; 6 61.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (127102125..127131913, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (127125162..127152188, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 23 Neighboring gene Trp53 induced glycolysis regulatory phosphatase Neighboring gene STARR-seq mESC enhancer starr_17405 Neighboring gene STARR-positive B cell enhancer ABC_E2208 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:127059715-127059898 Neighboring gene STARR-seq mESC enhancer starr_17406 Neighboring gene STARR-positive B cell enhancer ABC_E2805 Neighboring gene RIKEN cDNA 9330179D12 gene Neighboring gene STARR-positive B cell enhancer ABC_E9676 Neighboring gene STARR-seq mESC enhancer starr_17407 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene triosephosphate isomerase related sequence 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway. Sun Q, et al. J Cell Sci, 2009 May 15. PMID 19401331
  2. Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability. Jedynak P, et al. Behav Brain Res, 2012 Feb 1. PMID 22101301
  3. Epileptogenesis following Kainic Acid-Induced Status Epilepticus in Cyclin D2 Knock-Out Mice with Diminished Adult Neurogenesis. Kondratiuk I, et al. PLoS One, 2015. PMID 26020770, Free PMC Article
  4. Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40. Lam EW, et al. J Biol Chem, 2000 Feb 4. PMID 10652342
  5. Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development. Solvason N, et al. Int Immunol, 2000 May. PMID 10784609

See all (397) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of individualized behavioral trajectories in adult neurogenesis-deficient cyclin D2 knockout mice.
    Title: Loss of individualized behavioral trajectories in adult neurogenesis-deficient cyclin D2 knockout mice.
  2. CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism.
    Title: CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism.
  3. SRSF1 promotes ASMC proliferation in asthma by competitively binding CCND2 with miRNA-135a.
    Title: SRSF1 promotes ASMC proliferation in asthma by competitively binding CCND2 with miRNA-135a.
  4. Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy.
    Title: Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy.
  5. Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
    Title: Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
  6. miR-135a Suppresses Granulosa Cell Growth by Targeting Tgfbr1 and Ccnd2 during Folliculogenesis in Mice.
    Title: miR-135a Suppresses Granulosa Cell Growth by Targeting Tgfbr1 and Ccnd2 during Folliculogenesis in Mice.
  7. Amniotic fluid mesenchymal stem cells repair mouse corneal cold injury by promoting mRNA N4-acetylcytidine modification and ETV4/JUN/CCND2 signal axis activation.
    Title: Amniotic fluid mesenchymal stem cells repair mouse corneal cold injury by promoting mRNA N4-acetylcytidine modification and ETV4/JUN/CCND2 signal axis activation.
  8. Testis-enriched circular RNA circ-Bbs9 plays an important role in Leydig cell proliferation by regulating a CyclinD2-dependent pathway.
    Title: Testis-enriched circular RNA circ-Bbs9 plays an important role in Leydig cell proliferation by regulating a CyclinD2-dependent pathway.
  9. Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation.
    Title: Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation.
  10. E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of cardiomyocyte.
    Title: Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin D2-CDK4 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cyclin D2-CDK4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G1/S-specific cyclin-D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009829.3 → NP_033959.1  G1/S-specific cyclin-D2

    See identical proteins and their annotated locations for NP_033959.1

    Status: VALIDATED

    Source sequence(s)
    AK147345, BY161742, CAAA01200960
    Consensus CDS
    CCDS20564.1
    UniProtKB/Swiss-Prot
    P30280
    UniProtKB/TrEMBL
    Q4FK45
    Related
    ENSMUSP00000000188.9, ENSMUST00000000188.12
    Conserved Domains (2) summary
    pfam00134
    Location:24 → 151
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:153 → 262
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    127102125..127131913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165787.1 → XP_036021680.1  G1/S-specific cyclin-D2 isoform X2

    Conserved Domains (2) summary
    cd20574
    Location:48 → 196
    CYCLIN_CCND2_rpt1; first cyclin box found in G1/S-specific cyclin-D2 (CCND2)
    cd20577
    Location:201 → 305
    CYCLIN_CCND2_rpt2; second cyclin box found in G1/S-specific cyclin-D2 (CCND2)

  2. XM_036165785.1 → XP_036021678.1  G1/S-specific cyclin-D2 isoform X1

    Conserved Domains (2) summary
    cd20574
    Location:61 → 209
    CYCLIN_CCND2_rpt1; first cyclin box found in G1/S-specific cyclin-D2 (CCND2)
    cd20577
    Location:214 → 318
    CYCLIN_CCND2_rpt2; second cyclin box found in G1/S-specific cyclin-D2 (CCND2)

  3. XM_036165786.1 → XP_036021679.1  G1/S-specific cyclin-D2 isoform X2

  4. XM_006505460.1 → XP_006505523.1  G1/S-specific cyclin-D2 isoform X3

    See identical proteins and their annotated locations for XP_006505523.1

    UniProtKB/Swiss-Prot
    P30280
    UniProtKB/TrEMBL
    Q4FK45
    Conserved Domains (2) summary
    pfam00134
    Location:24 → 151
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:153 → 262
    Cyclin_C; Cyclin, C-terminal domain

  5. XM_006505459.3 → XP_006505522.1  G1/S-specific cyclin-D2 isoform X3

    See identical proteins and their annotated locations for XP_006505522.1

    UniProtKB/Swiss-Prot
    P30280
    UniProtKB/TrEMBL
    Q4FK45
    Conserved Domains (2) summary
    pfam00134
    Location:24 → 151
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:153 → 262
    Cyclin_C; Cyclin, C-terminal domain

  6. XM_036165788.1 → XP_036021681.1  G1/S-specific cyclin-D2 isoform X4

  7. XM_036165789.1 → XP_036021682.1  G1/S-specific cyclin-D2 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30280.1 GenPept UniProtKB/Swiss-Prot:P30280

Gene LinkOut

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