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Cckbr cholecystokinin B receptor [ Mus musculus (house mouse) ]

Gene ID: 12426, updated on 2-Nov-2024

Summary

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Official Symbol
Cckbrprovided by MGI
Official Full Name
cholecystokinin B receptorprovided by MGI
Primary source
MGI:MGI:99479
See related
Ensembl:ENSMUSG00000030898 AllianceGenome:MGI:99479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCK2R; CCK-BR; CCK2-R; CCKR-2
Summary
This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]
Expression
Biased expression in cortex adult (RPKM 23.1), frontal lobe adult (RPKM 18.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Cckbr in Genome Data Viewer
Location:
7 E3; 7 55.86 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105075201..105085546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105425676..105436339)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene STARR-positive B cell enhancer ABC_E3739 Neighboring gene cyclic nucleotide gated channel alpha 4 Neighboring gene predicted gene 4972 Neighboring gene STARR-seq mESC enhancer starr_19745 Neighboring gene STARR-seq mESC enhancer starr_19746 Neighboring gene caveolae associated 3 Neighboring gene predicted gene, 36847

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice. Clerc P, et al. Endocrinology, 2007 Mar. PMID 17122076
  2. Social defeat increases alcohol preference of C57BL/10 strain mice; effect prevented by a CCKB antagonist. Croft AP, et al. Psychopharmacology (Berl), 2005 Dec. PMID 16205917
  3. Cat odour exposure decreases exploratory activity and alters neuropeptide gene expression in CCK(2) receptor deficient mice, but not in their wild-type littermates. Areda T, et al. Behav Brain Res, 2006 May 15. PMID 16488027
  4. Elevated cholecystokininergic tone constitutes an important molecular/neuronal mechanism for the expression of anxiety in the mouse. Chen Q, et al. Proc Natl Acad Sci U S A, 2006 Mar 7. PMID 16537459, Free PMC Article
  5. CCK(2) receptor nullification attenuates lipopolysaccharide-induced sickness behavior. Weiland TJ, et al. Am J Physiol Regul Integr Comp Physiol, 2007 Jan. PMID 16857893

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Implicating the cholecystokinin B receptor in liver stem cell oncogenesis.
    Title: Implicating the cholecystokinin B receptor in liver stem cell oncogenesis.
  2. CCK2-receptor deficiency impairs immune balance by influencing CD4[+] T cells development by inhibiting cortical-thymic-epithelial-cells.
    Title: CCK2-receptor deficiency impairs immune balance by influencing CD4(+) T cells development by inhibiting cortical-thymic-epithelial-cells.
  3. Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.
    Title: Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.
  4. Effect of GRK4 on renal gastrin receptor regulation in hypertension.
    Title: Effect of GRK4 on renal gastrin receptor regulation in hypertension.
  5. Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.
    Title: Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.
  6. weevaluated the chemopreventive potential of two CCK2R antagonists,JNJ-26070109 and YF476, against pancreatic cancer using the genetically engineered mice
    Title: Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.
  7. Our data suggest a progression model for BE to EAC in which CCK2R+ progenitor cells, stimulated by hypergastrinemia, proliferate to give rise to metaplasia and dysplasia.
    Title: Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus.
  8. CCKBR and D5R synergistically interact in the kidney, which may contribute to the maintenance of normal sodium balance following an increase in sodium intake
    Title: The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion.
  9. findings provide novel evidence that Cnr1 contributes to cued fear expression via an interaction with the CCKB receptor.
    Title: Interaction between the cholecystokinin and endogenous cannabinoid systems in cued fear expression and extinction retention.
  10. There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
    Title: Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholecystokinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholecystokinin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables gastrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gastrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables gastrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables type B gastrin/cholecystokinin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables type B gastrin/cholecystokinin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in behavioral defense response ISO
Inferred from Sequence Orthology
more info
  
involved_in cholecystokinin signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in estrous cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gastric acid secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in histamine secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pH reduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of somatostatin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gastrin/cholecystokinin type B receptor
Names
CCK-B receptor
CCK-B/gastrin receptor
CCK2/gastrin receptor
cholecystokinin-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412224.1 → NP_001399153.1  gastrin/cholecystokinin type B receptor isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC125055

  2. NM_007627.6 → NP_031653.1  gastrin/cholecystokinin type B receptor isoform 1

    See identical proteins and their annotated locations for NP_031653.1

    Status: REVIEWED

    Source sequence(s)
    AC125055
    Consensus CDS
    CCDS21651.1
    UniProtKB/Swiss-Prot
    P56481
    UniProtKB/TrEMBL
    Q3ZB46, Q8BKF6
    Related
    ENSMUSP00000033189.4, ENSMUST00000033189.6
    Conserved Domains (2) summary
    pfam00001
    Location:71 → 396
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:60 → 191
    7tm_4; Olfactory receptor

RNA

  1. NR_178082.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC125055

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105075201..105085546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56481.1 GenPept UniProtKB/Swiss-Prot:P56481

Gene LinkOut

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