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Bard1 BRCA1 associated RING domain 1 [ Mus musculus (house mouse) ]

Gene ID: 12021, updated on 2-Nov-2024

Summary

Official Symbol
Bard1provided by MGI
Official Full Name
BRCA1 associated RING domain 1provided by MGI
Primary source
MGI:MGI:1328361
See related
Ensembl:ENSMUSG00000026196 AllianceGenome:MGI:1328361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable RNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of protein export from nucleus; protein K6-linked ubiquitination; and regulation of apoptotic process. Located in nucleus. Is expressed in central nervous system; genitourinary system; limb; and spleen. Used to study breast cancer. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 5.7), liver E14.5 (RPKM 5.1) and 18 other tissues See more
Orthologs
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Genomic context

See Bard1 in Genome Data Viewer
Location:
1 C3; 1 35.67 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (71066694..71142300, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (71027535..71103141, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene von Willebrand factor C domain-containing protein 2-like Neighboring gene STARR-seq mESC enhancer starr_01230 Neighboring gene predicted gene, 29906 Neighboring gene predicted gene, 57799 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5769 Neighboring gene STARR-seq mESC enhancer starr_01231 Neighboring gene STARR-seq mESC enhancer starr_01232 Neighboring gene predicted gene, 53490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:71149481-71149668 Neighboring gene STARR-seq mESC enhancer starr_01235 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 53560

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in DNA damage response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in DNA strand resection involved in replication fork processing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in homologous recombination NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic G2/M transition checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein K6-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA damage checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-A complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of BRCA1-B complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-BARD1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BRCA1-BARD1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-BARD1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of BRCA1-C complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
BRCA1-associated RING domain protein 1
Names
BARD-1
RING-type E3 ubiquitin transferase BARD1
NP_001406889.1
NP_031551.1
XP_006495695.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419960.1NP_001406889.1  BRCA1-associated RING domain protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104747
  2. NM_007525.3NP_031551.1  BRCA1-associated RING domain protein 1 isoform 1

    See identical proteins and their annotated locations for NP_031551.1

    Status: VALIDATED

    Source sequence(s)
    AC104747
    Consensus CDS
    CCDS15029.1
    UniProtKB/Swiss-Prot
    A2VCQ1, O70445
    UniProtKB/TrEMBL
    Q3ULG2
    Related
    ENSMUSP00000027393.8, ENSMUST00000027393.8
    Conserved Domains (6) summary
    smart00292
    Location:558628
    BRCT; breast cancer carboxy-terminal domain
    cd00204
    Location:412532
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:420512
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:391436
    Ank_4; Ankyrin repeats (many copies)
    pfam14835
    Location:3599
    zf-RING_6; zf-RING of BARD1-type protein
    sd00045
    Location:415446
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    71066694..71142300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495632.4XP_006495695.1  BRCA1-associated RING domain protein 1 isoform X2

    Conserved Domains (4) summary
    sd00045
    Location:415446
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:420510
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:391436
    Ank_4; Ankyrin repeats (many copies)
    pfam14835
    Location:3599
    zf-RING_6; zf-RING of BARD1-type protein

RNA

  1. XR_003947336.1 RNA Sequence