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B3gat1 beta-1,3-glucuronyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117108, updated on 17-Aug-2024

Summary

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Official Symbol
B3gat1provided by RGD
Official Full Name
beta-1,3-glucuronyltransferase 1provided by RGD
Primary source
RGD:70880
See related
EnsemblRapid:ENSRNOG00000007142 AllianceGenome:RGD:70880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnk-1
Summary
Enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Involved in cellular response to hypoxia. Located in Golgi membrane and endoplasmic reticulum membrane. Biomarker of pulmonary fibrosis. Orthologous to human B3GAT1 (beta-1,3-glucuronyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 99.8), Kidney (RPKM 16.0) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See B3gat1 in Genome Data Viewer
Location:
8q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (33362791..33390446)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (25087123..25114692)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (27777024..27804368)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479971 Neighboring gene uncharacterized LOC120094098 Neighboring gene U7 small nuclear RNA Neighboring gene galactosidase, beta 1-like 2 Neighboring gene galactosidase, beta 1-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glycosyltransferases and glycosaminoglycans in bleomycin and transforming growth factor-β1-induced pulmonary fibrosis. Venkatesan N, et al. Am J Respir Cell Mol Biol, 2014 Mar. PMID 24127863
  2. Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins. Gogate SS, et al. Arthritis Rheum, 2011 Jul. PMID 21400481, Free PMC Article
  3. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. Hiyama A, et al. J Bone Miner Res, 2010 May. PMID 19961337, Free PMC Article
  4. Mechanism of trifluralin-induced thyroid tumors in rats. Saghir SA, et al. Toxicol Lett, 2008 Jul 30. PMID 18582544
  5. Polysialic acid and HNK-1 are expressed in the adult rat vestibular endorgans. Isawa M, et al. Neuroreport, 2004 Jul 19. PMID 15232286

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. positive expression for Osterix and HNK1 in undifferentiated ectomesenchymal cells in early and late stages
    Title: Temporo-spatial analysis of Osterix, HNK1 and Sox10 during odontogenesis and maxillaries osteogenesis.
  2. increased expression of CS-GAGs and GlcAT-I in fibrotic lungs and fibrotic lung fibroblasts
    Title: Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of β1,3-glucuronosyltransferase I in pulmonary fibrosis.
  3. Results of these studies demonstrate that BMP-2 and TGF-beta regulate GlcAT-1 expression in nucleus pulposus cells through a signaling network comprising MAPK, AP1, Sp1, and TonEBP
    Title: BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs.
  4. TonEBP activation by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
    Title: Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc.
  5. Trifluralin-induced total hepatic UGT enzymes (2.4-fold) and mRNA expression of selected hepatic UGT isozymes (UGT1A1, 1.4-fold; UGT1A6, 6.4-fold; UGT2B1, 3.7-fold).
    Title: Mechanism of trifluralin-induced thyroid tumors in rats.
  6. These results combined suggest that both PSA and HNK-1 carbohydrate epitopes are synthesized and may have an important role in the adult peripheral vestibular endorgans.
    Title: Polysialic acid and HNK-1 are expressed in the adult rat vestibular endorgans.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Names
UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase
glcAT-P
glcUAT-P
glucuronosyltransferase P
NP_446455.1
XP_006242796.1
XP_038936638.1
XP_038936641.1
XP_063120855.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054003.1 → NP_446455.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

    See identical proteins and their annotated locations for NP_446455.1

    Status: PROVISIONAL

    Source sequence(s)
    D88035
    UniProtKB/Swiss-Prot
    O35789
    Related
    ENSRNOP00000009825.5, ENSRNOT00000009825.7
    Conserved Domains (1) summary
    pfam03360
    Location:118 → 328
    Glyco_transf_43; Glycosyltransferase family 43

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    33362791..33390446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264785.1 → XP_063120855.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X2

  2. XM_039080710.2 → XP_038936638.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    A0A0H2UHF1, O35789
    UniProtKB/TrEMBL
    A6JYC4
    Conserved Domains (1) summary
    pfam03360
    Location:105 → 315
    Glyco_transf_43; Glycosyltransferase family 43

  3. XM_039080713.2 → XP_038936641.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    A0A0H2UHF1, O35789
    UniProtKB/TrEMBL
    A6JYC4
    Conserved Domains (1) summary
    pfam03360
    Location:105 → 315
    Glyco_transf_43; Glycosyltransferase family 43

  4. XM_006242734.5 → XP_006242796.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006242796.1

    UniProtKB/Swiss-Prot
    A0A0H2UHF1, O35789
    UniProtKB/TrEMBL
    A6JYC4
    Conserved Domains (1) summary
    pfam03360
    Location:105 → 315
    Glyco_transf_43; Glycosyltransferase family 43
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35789.2 GenPept UniProtKB/Swiss-Prot:O35789

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