Calb2 calbindin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Calb2provided by RGD
Full Name: calbindin 2provided by RGD
Primary source: RGD:620981
See related: Ensembl:ENSRNOG00000016977 AllianceGenome:RGD:620981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium ion binding activity. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Located in cuticular plate; nucleus; and stereocilium. Is active in synaptic membrane. Orthologous to human CALB2 (calbindin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 382.5) and Testes (RPKM 140.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (55023849..55050858, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (38114435..38141438, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (41482743..41509617)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging.
Title: Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging.
Quantitative analysis of the transient changes in calretinin expression by hybridochemistry within neuronal cell populations in the hippocampus of a beta amyloid-treated rat model of Alzheimer's disease and their correlation with endocannabinoid increase
Title: Analysis of calretinin early expression in the rat hippocampus after beta amyloid (1-42) peptide injection.
A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel
Title: [A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel].
distribution of the cell-specific markers, calretinin and calbindin, in reelin-immunoreactive cells during postnatal rat and mouse neocortical development
Title: Expression of calcium-binding proteins in layer 1 reelin-immunoreactive cells during rat and mouse neocortical development.
The stress of maternal deprivation has a significant effect on calretinin and calbindin expression in both male and female ratss, but affects glucocorticoid receptor levels only in males.
Title: The effect of different maternal deprivation paradigms on the expression of hippocampal glucocorticoid receptors, calretinin and calbindin-D28k in male and female adolescent rats.
An essential property of calretinin action potentials is a delayed equilibration with divalent calcium ions.
Title: Effects of calretinin on Ca2+ signals in cerebellar granule cells: implications of cooperative Ca2+ binding.
Studied the general pattern of calretinin (CR), parvalbumin (PV) and calbindin (CB) immunoreactivity as well as morphological features and density of CR and PV immunoreactive (CR+, PV+) interneurons in the rat perirhinal cortex (PRC) and found the PRC possesses specific interneuronal equipment with unusually high proportion of CR+ interneurons.
Title: Calretinin, parvalbumin and calbindin immunoreactive interneurons in perirhinal cortex and temporal area Te3V of the rat brain: qualitative and quantitative analyses.
results suggest that hypothyroidism ameliorated the diabetes-induced reduction of CB, CR, and PV immunoreactivity in the hippocampus
Title: Hypothyroid states mitigate the diabetes-induced reduction of calbindin D-28k, calretinin, and parvalbumin immunoreactivity in type 2 diabetic rats.
study concludes that, in inner and outer enamel epithelial cells, Ca(2+)is regulated by calbindin, parvalbumin and calretinin during tooth development; in epithelial rests of Malassez of adult periodontal ligament, Ca(2+) is regulated only by calretinin
Title: The Ca(2+)-binding protein calretinin is selectively enriched in a subpopulation of the epithelial rests of Malassez.
There is a clear compartmentalization of calbindin-28 kDa and calretinin distribution in retinal ganglion cells.
Title: Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

RH138609 (e-PCR)
- UniSTS:220696

d19rat71 (e-PCR)
- UniSTS:121416

X73985 (e-PCR)
- UniSTS:179819

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cuticular plate	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in parallel fiber to Purkinje cell synapse	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	HDA more info	PubMed
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in vestibular calyx terminal	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calretinin

Names: CR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.