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E2f5 E2F transcription factor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116651, updated on 10-Jul-2024

Summary

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Official Symbol
E2f5provided by RGD
Official Full Name
E2F transcription factor 5provided by RGD
Primary source
RGD:621357
See related
EnsemblRapid:ENSRNOG00000010760 AllianceGenome:RGD:621357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
E2f-5
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within animal organ morphogenesis and regulation of transcription, DNA-templated. Located in nucleus and sarcoplasm. Orthologous to human E2F5 (E2F transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 61.8), Adrenal (RPKM 50.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See E2f5 in Genome Data Viewer
Location:
2q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (88718567..88734143, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (86997331..87012908, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (88350764..88366913, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 1 Neighboring gene carbonic anhydrase 13 Neighboring gene peroxiredoxin like 2A, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) Neighboring gene ribosomal biogenesis factor Neighboring gene leucine rich repeat and coiled-coil centrosomal protein 1 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F. Hayashi R, et al. Gene, 2006 Feb 15. PMID 16325355
  2. miR‑132 inhibits high glucose‑induced vascular smooth muscle cell proliferation and migration by targeting E2F5. Xu Q, et al. Mol Med Rep, 2019 Aug. PMID 31257477
  3. Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy. Vara D, et al. J Biol Chem, 2003 Jun 13. PMID 12682052
  4. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Lindeman GJ, et al. Genes Dev, 1998 Apr 15. PMID 9553039, Free PMC Article
  5. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. Itoh A, et al. Cell Mol Biol Res, 1995. PMID 8589754

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR132 was proposed to inhibit the proliferation and migration of diabetic rat or highglucosetreated vascular smooth muscle cells (VSMCs) by targeting E2F5
    Title: miR‑132 inhibits high glucose‑induced vascular smooth muscle cell proliferation and migration by targeting E2F5.
  2. E2F transcription factor genes and their 34 target genes have a role in liver regeneration.
    Title: Analysis of the relevance of e2fs and their target genes with rat liver regeneration.
  3. E2F2, unlike E2F1, E2F3 and E2F5, does not induce apoptosis but even suppresses expression of several pro-apoptotic genes in primary cardiomyocytes; E2F1, E2F2, and E2F3 and E2F4 induce S-phase entry of primary cardiomyocytes
    Title: Making omelets without breaking eggs: E2F-mediated induction of cardiomyoycte cell proliferation without stimulation of apoptosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor E2F5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398639.1 → NP_001385568.1  transcription factor E2F5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q62814
    UniProtKB/TrEMBL
    F1LRB5
    Related
    ENSRNOP00000044464.5, ENSRNOT00000044847.6
    Conserved Domains (2) summary
    cd14660
    Location:121 → 225
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:45 → 109
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    88718567..88734143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281169.1 → XP_063137239.1  transcription factor E2F5 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AF40

  2. XM_063281167.1 → XP_063137237.1  transcription factor E2F5 isoform X2

  3. XM_063281166.1 → XP_063137236.1  transcription factor E2F5 isoform X1

    UniProtKB/Swiss-Prot
    Q62814

  4. XM_063281168.1 → XP_063137238.1  transcription factor E2F5 isoform X3

RNA

  1. XR_010063578.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62814.1 GenPept UniProtKB/Swiss-Prot:Q62814

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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