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Map3k8 mitogen-activated protein kinase kinase kinase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116596, updated on 2-Nov-2024

Summary

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Official Symbol
Map3k8provided by RGD
Official Full Name
mitogen-activated protein kinase kinase kinase 8provided by RGD
Primary source
RGD:620969
See related
EnsemblRapid:ENSRNOG00000016378 AllianceGenome:RGD:620969
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tpl2; Tpl-2; D17TPL2
Summary
Enables MAP kinase kinase kinase activity. Involved in cardiac ventricle development and gap junction-mediated intercellular transport. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma; lung cancer; and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 108.2), Lung (RPKM 65.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Map3k8 in Genome Data Viewer
Location:
17q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58078175..58098455)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (53382908..53403216)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (56109403..56129925)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097757 Neighboring gene uncharacterized LOC134482858 Neighboring gene mitochondrial poly(A) polymerase Neighboring gene ribosomal protein L27A like 1 Neighboring gene lysozyme-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy. Lai DW, et al. Circ Res, 2017 Sep 1. PMID 28724746
  2. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Patriotis C, et al. Proc Natl Acad Sci U S A, 1993 Mar 15. PMID 7681591, Free PMC Article
  3. Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion. Makris A, et al. J Virol, 1993 Jul. PMID 8510223, Free PMC Article
  4. Overexpression of the Tpl-2/Cot oncogene in human breast cancer. Sourvinos G, et al. Oncogene, 1999 Sep 2. PMID 10490831
  5. Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells. Chikamatsu S, et al. Mol Immunol, 2007 Mar. PMID 17049604

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This finding gives a new insight into the role of Cot in the FcvarepsilonRI-mediated NF-kappaB activation in mast cells.
    Title: Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac ventricle development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in gap junction-mediated intercellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 8
Names
serine/threonine kinase (Tpl-2)
tumor progression locus 2
NP_446299.2
XP_006254110.2
XP_038951219.1
XP_038951221.1
XP_038951222.1
XP_063132092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053847.2 → NP_446299.2  mitogen-activated protein kinase kinase kinase 8

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q63562
    UniProtKB/TrEMBL
    A6K9G3
    Conserved Domains (1) summary
    cd13995
    Location:133 → 388
    STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    58078175..58098455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276022.1 → XP_063132092.1  mitogen-activated protein kinase kinase kinase 8 isoform X4

  2. XM_006254048.3 → XP_006254110.2  mitogen-activated protein kinase kinase kinase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q63562
    UniProtKB/TrEMBL
    A6K9G3
    Related
    ENSRNOP00000022190.2, ENSRNOT00000022190.5
    Conserved Domains (1) summary
    cd13995
    Location:133 → 388
    STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8

  3. XM_039095293.2 → XP_038951221.1  mitogen-activated protein kinase kinase kinase 8 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:2 → 231
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039095291.2 → XP_038951219.1  mitogen-activated protein kinase kinase kinase 8 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:2 → 231
    PKc_like; Protein Kinases, catalytic domain

  5. XM_039095294.2 → XP_038951222.1  mitogen-activated protein kinase kinase kinase 8 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 182
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63562.1 GenPept UniProtKB/Swiss-Prot:Q63562

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