Timp1 TIMP metallopeptidase inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Timp1provided by RGD
Official Full Name: TIMP metallopeptidase inhibitor 1provided by RGD
Primary source: RGD:621675
See related: EnsemblRapid:ENSRNOG00000010208 AllianceGenome:RGD:621675
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Timp; TIMP-1
Summary: Enables protease binding activity. Involved in several processes, including cartilage development; cellular response to peptide; and response to peptide hormone. Located in basement membrane. Used to study degenerative disc disease. Biomarker of several diseases, including gastric ulcer; heart disease (multiple); lung disease (multiple); metabolic dysfunction-associated steatohepatitis; and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 146.9), Uterus (RPKM 130.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (3766509..3772578, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (1212969..1217714, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (1364771..1369451, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression.
Title: GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression.
TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation.
Title: TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation.
Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemiareperfusion injury by promoting angiogenesis and inhibiting oxidative stress.
Title: Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress.
TIMP-1: A key cytokine released from activated astrocytes protects neurons and ameliorates cognitive behaviours in a rodent model of Alzheimer's disease.
Title: TIMP-1: A key cytokine released from activated astrocytes protects neurons and ameliorates cognitive behaviours in a rodent model of Alzheimer's disease.
Inhibition of histone demethylase JMJD1C attenuates cardiac hypertrophy and fibrosis induced by angiotensin II.
Title: Inhibition of histone demethylase JMJD1C attenuates cardiac hypertrophy and fibrosis induced by angiotensin II.
Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo.
Title: Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo.
MMP9 and TIMP-1 may have a role in tissue remodeling in a rat model of heart failure
Title: Molecular evidence of tissue remodeling in an animal model of heart failure.
The present study is the first to demonstrate that cold exposure exacerbates imbalance between MMP-9 and TIMP-1 by activating the RAS, which may be critical in the initiation of stroke during chronic hypertension
Title: Renin-angiotensin system activation and imbalance of matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinase-1 in cold-induced stroke.
These data provide a previously uncharacterized trophic action of TIMP-1 to regulate oligodendrocyte maturation via a CD63/beta1-integrin/Akt pathway mechanism.
Title: TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling.
Overexpression of prolyl-hydroxylase 2 (PHD2) transgene, a predominant isoform of PHDs in renal tubules, to reduce HIF-1alpha level significantly attenuated albumin-induced increases in TIMP-1 and collagen-I levels. These results suggest that albumin-induced oxidative stress inhibits PHD activity to accumulate HIF-1alpha, which mediates albumin-induced profibrotic effects in renal tubular cells
Title: Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells.

Submit: New GeneRIF Correction See all GeneRIFs (99)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metalloendopeptidase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cartilage development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to UV-A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-A	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to peptide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catalytic activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metallopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metalloproteinase inhibitor 1

Names: tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053819.1 → NP_446271.1 metalloproteinase inhibitor 1 precursor

See identical proteins and their annotated locations for NP_446271.1

Status: PROVISIONAL

Source sequence(s)

L31883

UniProtKB/Swiss-Prot

P30120, P70533, Q53YM7

UniProtKB/TrEMBL

A6JZR1

Related

ENSRNOP00000013745.4, ENSRNOT00000013745.9

Conserved Domains (1) summary

smart00206
Location:24 → 199

NTR; Tissue inhibitor of metalloproteinase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

3766509..3772578 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256608.4 → XP_006256670.1 metalloproteinase inhibitor 1 isoform X1

See identical proteins and their annotated locations for XP_006256670.1

UniProtKB/Swiss-Prot

P30120, P70533, Q53YM7

UniProtKB/TrEMBL

A6JZR1

Conserved Domains (1) summary

smart00206
Location:24 → 199

NTR; Tissue inhibitor of metalloproteinase family
XM_039099406.2 → XP_038955334.1 metalloproteinase inhibitor 1 isoform X1

UniProtKB/Swiss-Prot

P30120, P70533, Q53YM7

UniProtKB/TrEMBL

A6JZR1

Conserved Domains (1) summary

smart00206
Location:24 → 199

NTR; Tissue inhibitor of metalloproteinase family
XM_039099407.2 → XP_038955335.1 metalloproteinase inhibitor 1 isoform X1

UniProtKB/Swiss-Prot

P30120, P70533, Q53YM7

UniProtKB/TrEMBL

A6JZR1

Conserved Domains (1) summary

smart00206
Location:24 → 199

NTR; Tissue inhibitor of metalloproteinase family