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CMTM5 CKLF like MARVEL transmembrane domain containing 5 [ Homo sapiens (human) ]

Gene ID: 116173, updated on 2-Nov-2024

Summary

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Official Symbol
CMTM5provided by HGNC
Official Full Name
CKLF like MARVEL transmembrane domain containing 5provided by HGNC
Primary source
HGNC:HGNC:19176
See related
Ensembl:ENSG00000166091 MIM:607888; AllianceGenome:HGNC:19176
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLFSF5
Summary
This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in brain (RPKM 15.6), bone marrow (RPKM 1.3) and 1 other tissue See more
Orthologs
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Genomic context

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See CMTM5 in Genome Data Viewer
Location:
14q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23376771..23379772)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17577688..17580788)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23846255..23848981)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832478-23832978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832979-23833479 Neighboring gene embryonal Fyn-associated substrate Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8171 Neighboring gene interleukin 25 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23854904-23856103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23858153-23858756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23858757-23859360 Neighboring gene myosin heavy chain 6 Neighboring gene microRNA 208a Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23871133-23871675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23871676-23872217 Neighboring gene VISTA enhancer hs2155 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23884455-23885654 Neighboring gene myosin heavy chain 7 Neighboring gene myosin heavy chain associated RNA transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CMTM5 influences Hippo/YAP axis to promote ferroptosis in glioma through regulating WWP2-mediated LATS2 ubiquitination. Fan Y, et al. Kaohsiung J Med Sci, 2024 Oct. PMID 39166861
  2. Aberrant expression of CKLF-like MARVEL transmembrane member 5 (CMTM5) by promoter methylation in myeloid leukemia. Niu J, et al. Leuk Res, 2011 Jun. PMID 21168207
  3. Reduced CMTM5 expression correlates with carcinogenesis in human epithelial ovarian cancer. Li P, et al. Int J Gynecol Cancer, 2011 Oct. PMID 21841490
  4. CMTM5 exhibits tumor suppressor activity through promoter methylation in oral squamous cell carcinoma. Zhang H, et al. Biochem Biophys Res Commun, 2014 May 2. PMID 24721428
  5. CMTM5 is reduced in prostate cancer and inhibits cancer cell growth in vitro and in vivo. Xiao Y, et al. Clin Transl Oncol, 2015 Jun. PMID 25387568

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CMTM5 influences Hippo/YAP axis to promote ferroptosis in glioma through regulating WWP2-mediated LATS2 ubiquitination.
    Title: CMTM5 influences Hippo/YAP axis to promote ferroptosis in glioma through regulating WWP2-mediated LATS2 ubiquitination.
  2. CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway.
    Title: CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway.
  3. CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.
    Title: CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.
  4. [Association between CMTM5 gene and coronary artery disease and the relative mechanism].
    Title: [Association between CMTM5 gene and coronary artery disease and the relative mechanism].
  5. [Association of CMTM5 gene expression with the risk of in-stent restenosis in patients with coronary artery disease after drug-eluting stent implantation and the effects and mechanisms of CMTM5 on human vascular endothelial cells].
    Title: [Association of CMTM5 gene expression with the risk of in-stent restenosis in patients with coronary artery disease after drug-eluting stent implantation and the effects and mechanisms of CMTM5 on human vascular endothelial cells].
  6. CMTM5 was down-regulated in the hepatocellular carcinoma tissues.Up-regulation of miR-10b-3p promoted the progression of the hepatocellular carcinoma cells via targeting CMTM5.
    Title: Up-regulation of miR-10b-3p promotes the progression of hepatocellular carcinoma cells via targeting CMTM5.
  7. Re-expression of CMTM5 inhibits the proliferative activity of U266
    Title: [Pathophysiologic mechanism of CMTM5 low expression in multiple myeloma progression].
  8. Overexpression of CMTM5 attenuated vascular endothelial cells migration and proliferation.
    Title: Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function.
  9. results indicate that CMTM5 is down-regulated in prostate cancer and exhibit tumor suppressor activities in androgen-independent prostate cancer cells
    Title: CMTM5 is reduced in prostate cancer and inhibits cancer cell growth in vitro and in vivo.
  10. In the OSCC cell lines CAL27 and GNM, the ectopic expression of CMTM5-v1 strongly inhibited cell proliferation and migration and induced apoptosis.
    Title: CMTM5 exhibits tumor suppressor activity through promoter methylation in oral squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37521

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 5
Names
chemokine-like factor super family 5
chemokine-like factor superfamily member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037288.2 → NP_001032365.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform c

    See identical proteins and their annotated locations for NP_001032365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AF479262, AY820135, BC013109
    Consensus CDS
    CCDS32050.1
    UniProtKB/Swiss-Prot
    Q96DZ9
    Related
    ENSP00000372259.2, ENST00000382809.2
    Conserved Domains (1) summary
    cl04571
    Location:29 → 105
    MARVEL; Membrane-associating domain

  2. NM_001288744.2 → NP_001275673.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform d

    See identical proteins and their annotated locations for NP_001275673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter, compared to isoform a.
    Source sequence(s)
    AF527949
    Consensus CDS
    CCDS73618.1
    UniProtKB/TrEMBL
    C9JAI6
    Related
    ENSP00000380404.3, ENST00000397227.7

  3. NM_001288745.2 → NP_001275674.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform e

    See identical proteins and their annotated locations for NP_001275674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AF527948
    Consensus CDS
    CCDS73619.1
    UniProtKB/Swiss-Prot
    Q96DZ9
    Related
    ENSP00000344160.4, ENST00000342473.8

  4. NM_001288746.2 → NP_001275675.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform f

    See identical proteins and their annotated locations for NP_001275675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (f) is longer, compared to isoform a.
    Source sequence(s)
    AF527413
    Consensus CDS
    CCDS73617.1
    UniProtKB/Swiss-Prot
    E9PH91, Q5PY48, Q96DZ9
    Related
    ENSP00000344819.4, ENST00000339180.9
    Conserved Domains (1) summary
    pfam01284
    Location:29 → 152
    MARVEL; Membrane-associating domain

  5. NM_138460.3 → NP_612469.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform a

    See identical proteins and their annotated locations for NP_612469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AL049829
    Consensus CDS
    CCDS9598.1
    UniProtKB/Swiss-Prot
    Q96DZ9
    Related
    ENSP00000352270.3, ENST00000359320.7
    Conserved Domains (1) summary
    pfam01284
    Location:29 → 139
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23376771..23379772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430907.1 → XP_047286863.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

  2. XM_047430906.1 → XP_047286862.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    Related
    ENSP00000497215.1, ENST00000649278.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17577688..17580788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375326.1 → XP_054231301.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

  2. XM_054375327.1 → XP_054231302.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181618.1: Suppressed sequence

    Description
    NM_181618.1: This RefSeq was permanently suppressed because it represents a likely non-sense mediated decay (NMD) candidate, there is insufficient support for the transcript and the protein is not supported by current protein hom
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DZ9.2 GenPept UniProtKB/Swiss-Prot:Q96DZ9

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