Agrn agrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agrnprovided by MGI
Official Full Name: agrinprovided by MGI
Primary source: MGI:MGI:87961
See related: Ensembl:ENSMUSG00000041936 AllianceGenome:MGI:87961
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Agrin; nmf380
Summary: Enables several functions, including chondroitin sulfate binding activity; heparan sulfate proteoglycan binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of sodium ion transmembrane transport; positive regulation of Rac protein signal transduction; and positive regulation of protein modification process. Acts upstream of or within several processes, including positive regulation of motor neuron apoptotic process; positive regulation of transcription by RNA polymerase II; and regulation of synaptic activity. Located in basement membrane; cell surface; and sarcolemma. Is active in extracellular space and synapse. Is expressed in several structures, including epithelium; lower jaw; musculature; nervous system; and retina. Used to study congenital myasthenic syndrome 8. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 86.1), CNS E14 (RPKM 82.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 88.55 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (156249747..156281997, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (156165290..156197533, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Agrin Inhibition in Enteric Neural Stem Cells Enhances Their Migration Following Colonic Transplantation.
Title: Agrin Inhibition in Enteric Neural Stem Cells Enhances Their Migration Following Colonic Transplantation.
Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice.
Title: Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice.
Synergistically Acting on Myostatin and Agrin Pathways Increases Neuromuscular Junction Stability and Endurance in Old Mice.
Title: Synergistically Acting on Myostatin and Agrin Pathways Increases Neuromuscular Junction Stability and Endurance in Old Mice.
The extracellular matrix protein Agrin is expressed by osteoblasts and contributes to their differentiation.
Title: The extracellular matrix protein Agrin is expressed by osteoblasts and contributes to their differentiation.
Agrin expression is correlated with tumor development and poor prognosis in cholangiocarcinoma.
Title: Agrin expression is correlated with tumor development and poor prognosis in cholangiocarcinoma.
Identification of the downstream molecules of agrin/Dok-7 signaling in muscle.
Title: Identification of the downstream molecules of agrin/Dok-7 signaling in muscle.
Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain.
Title: Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain.
Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Agrin signaling and autophagy
Title: Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Agrin signaling and autophagy.
Together, these observations identify a role of Agrin-Lrp4-Ror2 signaling for adult neurogenesis, uncovering previously unexpected functions of Agrin and Lrp4 in the brain.
Title: Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice.
MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion.
Title: MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224528

D18S1095 (e-PCR)
- UniSTS:34940

RH94447 (e-PCR)
- UniSTS:119695

D1S3697 (e-PCR)
- UniSTS:474275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables chondroitin sulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables dystroglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparan sulfate proteoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables sialic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of P-type sodium:potassium-exchanging transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of sodium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neuromuscular junction development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromuscular junction development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plasma membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Rac protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rac protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein geranylgeranylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within receptor clustering	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of axon guidance	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle acetylcholine-gated channel clustering	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: agrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369026.2 → NP_001355955.1 agrin isoform 2

Status: VALIDATED

Source sequence(s)

AL928667, CT998563

Consensus CDS

CCDS89874.1

UniProtKB/Swiss-Prot

A2ASP9, A2ASQ0, A2ASQ1, B2RWU1

UniProtKB/TrEMBL

Z4YK85

Related

ENSMUSP00000101200.3, ENSMUST00000105575.9

Conserved Domains (7) summary

smart00280
Location:384 → 429

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1014 → 1138

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1707 → 1739

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:316 → 356

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00050
Location:244 → 284

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00053
Location:688 → 735

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1282 → 1413

Laminin_G_1; Laminin G domain
NM_001369027.2 → NP_001355956.1 agrin isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CT998563

Conserved Domains (1) summary

pfam03146
Location:46 → 148

NtA; Agrin NtA domain
NM_021604.3 → NP_067617.3 agrin isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL928667, CT998563

Consensus CDS

CCDS19060.2

UniProtKB/TrEMBL

M0QWP1, Z4YK85

Related

ENSMUSP00000137931.2, ENSMUST00000180572.2

Conserved Domains (8) summary

smart00280
Location:491 → 536

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1121 → 1245

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1810 → 1842

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:423 → 463

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00050
Location:351 → 391

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00053
Location:795 → 837

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1389 → 1520

Laminin_G_1; Laminin G domain

pfam03146
Location:46 → 148

NtA; Agrin NtA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

156249747..156281997 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163604.1 → XP_036019497.1 agrin isoform X5

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (9) summary

smart00280
Location:491 → 536

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1121 → 1245

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1810 → 1842

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:423 → 463

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00008
Location:1322 → 1352

EGF; EGF-like domain

pfam00053
Location:795 → 837

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1389 → 1520

Laminin_G_1; Laminin G domain

pfam03146
Location:46 → 148

NtA; Agrin NtA domain

cl00097
Location:351 → 391

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
XM_011250176.3 → XP_011248478.1 agrin isoform X2

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (10) summary

smart00280
Location:491 → 536

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1121 → 1245

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1810 → 1842

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:795 → 835

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00104
Location:423 → 463

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00008
Location:1322 → 1352

EGF; EGF-like domain

pfam00050
Location:351 → 391

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00054
Location:1389 → 1520

Laminin_G_1; Laminin G domain

pfam00053
Location:849 → 885

Laminin_EGF; Laminin EGF domain

pfam03146
Location:46 → 148

NtA; Agrin NtA domain
XM_006538494.5 → XP_006538557.1 agrin isoform X6

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (9) summary

smart00280
Location:491 → 536

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1121 → 1245

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1814 → 1846

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:795 → 835

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00104
Location:423 → 463

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00050
Location:351 → 391

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00054
Location:1389 → 1520

Laminin_G_1; Laminin G domain

pfam00053
Location:849 → 885

Laminin_EGF; Laminin EGF domain

pfam03146
Location:46 → 148

NtA; Agrin NtA domain
XM_006538492.3 → XP_006538555.1 agrin isoform X3

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (10) summary

smart00280
Location:491 → 536

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1121 → 1245

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1814 → 1846

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:795 → 835

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00104
Location:423 → 463

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00008
Location:1322 → 1352

EGF; EGF-like domain

pfam00050
Location:351 → 391

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00054
Location:1389 → 1520

Laminin_G_1; Laminin G domain

pfam00053
Location:849 → 885

Laminin_EGF; Laminin EGF domain

pfam03146
Location:46 → 148

NtA; Agrin NtA domain
XM_006538493.3 → XP_006538556.1 agrin isoform X4

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (10) summary

smart00280
Location:491 → 536

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1121 → 1245

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1814 → 1846

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:795 → 835

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00104
Location:423 → 463

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00008
Location:1322 → 1352

EGF; EGF-like domain

pfam00050
Location:351 → 391

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00054
Location:1389 → 1520

Laminin_G_1; Laminin G domain

pfam00053
Location:849 → 885

Laminin_EGF; Laminin EGF domain

pfam03146
Location:46 → 148

NtA; Agrin NtA domain
XM_006538491.3 → XP_006538554.1 agrin isoform X1

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (10) summary

smart00280
Location:491 → 536

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1121 → 1245

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1814 → 1846

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:795 → 835

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00104
Location:423 → 463

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00008
Location:1322 → 1352

EGF; EGF-like domain

pfam00050
Location:351 → 391

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00054
Location:1389 → 1520

Laminin_G_1; Laminin G domain

pfam00053
Location:849 → 885

Laminin_EGF; Laminin EGF domain

pfam03146
Location:46 → 148

NtA; Agrin NtA domain
XM_006538496.4 → XP_006538559.1 agrin isoform X8

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (8) summary

smart00280
Location:323 → 368

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:953 → 1077

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1646 → 1678

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:627 → 667

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00104
Location:255 → 295

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00050
Location:183 → 223

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00054
Location:1221 → 1352

Laminin_G_1; Laminin G domain

pfam00053
Location:681 → 717

Laminin_EGF; Laminin EGF domain
XM_006538495.4 → XP_006538558.1 agrin isoform X7

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (8) summary

smart00280
Location:384 → 429

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:1014 → 1138

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1707 → 1739

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:688 → 728

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00104
Location:316 → 356

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00050
Location:244 → 284

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00054
Location:1282 → 1413

Laminin_G_1; Laminin G domain

pfam00053
Location:742 → 778

Laminin_EGF; Laminin EGF domain
XM_017319921.1 → XP_017175410.1 agrin isoform X9

UniProtKB/TrEMBL

Z4YK85

Conserved Domains (8) summary

smart00280
Location:257 → 302

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:887 → 1011

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1580 → 1612

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:561 → 601

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00104
Location:189 → 229

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00050
Location:117 → 157

Kazal_1; Kazal-type serine protease inhibitor domain

pfam00054
Location:1155 → 1286

Laminin_G_1; Laminin G domain

pfam00053
Location:615 → 651

Laminin_EGF; Laminin EGF domain
XM_036163605.1 → XP_036019498.1 agrin isoform X11

UniProtKB/TrEMBL

Q6PCM6

Conserved Domains (6) summary

smart00280
Location:162 → 209

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:359 → 483

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1052 → 1084

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:560 → 590

EGF; EGF-like domain

pfam00053
Location:33 → 84

Laminin_EGF; Laminin EGF domain

pfam00054
Location:627 → 758

Laminin_G_1; Laminin G domain
XM_030253098.1 → XP_030108958.1 agrin isoform X11

UniProtKB/TrEMBL

Q6PCM6

Conserved Domains (6) summary

smart00280
Location:162 → 209

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:359 → 483

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1052 → 1084

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:560 → 590

EGF; EGF-like domain

pfam00053
Location:33 → 84

Laminin_EGF; Laminin EGF domain

pfam00054
Location:627 → 758

Laminin_G_1; Laminin G domain
XM_011250178.1 → XP_011248480.1 agrin isoform X10

Conserved Domains (7) summary

smart00280
Location:37 → 82

KAZAL; Kazal type serine protease inhibitors

smart00200
Location:602 → 726

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

cd00054
Location:1295 → 1327

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:276 → 316

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00008
Location:803 → 833

EGF; EGF-like domain

pfam00054
Location:870 → 1001

Laminin_G_1; Laminin G domain

pfam00053
Location:330 → 366

Laminin_EGF; Laminin EGF domain