U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ada adenosine deaminase [ Mus musculus (house mouse) ]

Gene ID: 11486, updated on 2-Nov-2024

Summary

Official Symbol
Adaprovided by MGI
Official Full Name
adenosine deaminaseprovided by MGI
Primary source
MGI:MGI:87916
See related
Ensembl:ENSMUSG00000017697 AllianceGenome:MGI:87916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables 2'-deoxyadenosine deaminase activity; adenosine deaminase activity; and zinc ion binding activity. Involved in several processes, including allantoin metabolic process; purine nucleoside monophosphate metabolic process; and purine ribonucleoside metabolic process. Acts upstream of or within several processes, including negative regulation of lymphocyte apoptotic process; positive regulation of lymphocyte activation; and purine nucleobase biosynthetic process. Located in cytoplasm. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Used to study adenosine deaminase deficiency. Human ortholog(s) of this gene implicated in asthma; colon cancer; pleural tuberculosis; severe combined immunodeficiency (multiple); and uterine fibroid. Orthologous to human ADA (adenosine deaminase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in small intestine adult (RPKM 276.4), placenta adult (RPKM 134.5) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ada in Genome Data Viewer
Location:
2 84.44 cM; 2 H3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163565703..163592154, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163726571..163750239, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine incorporator 3 Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene STARR-positive B cell enhancer ABC_E819 Neighboring gene STARR-seq mESC enhancer starr_06314 Neighboring gene STARR-positive B cell enhancer ABC_E2058 Neighboring gene protein kinase inhibitor, gamma Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase upstream regulatory elements Neighboring gene cellular communication network factor 5 Neighboring gene potassium channel, subfamily K, member 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Not Applicable (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2'-deoxyadenosine deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 2'-deoxyadenosine deaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenosine deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenosine deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables adenosine deaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables deaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables purine nucleoside binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in AMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in AMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in IMP salvage TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within Peyer's patch development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenosine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenosine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adenosine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adenosine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in adenosine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in adenosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in allantoin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in allantoin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in dAMP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dATP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dATP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within deoxyadenosine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within deoxyadenosine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in deoxyadenosine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germinal center B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histamine secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hypoxanthine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hypoxanthine salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inhibition of non-skeletal tissue mineralization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in inosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inosine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inosine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within inosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mature B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mucus secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of adenosine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of adenosine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mature B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mucus secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of penile erection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of penile erection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in purine nucleotide salvage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell-cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to purine-containing compound IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin E ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trophectodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within xanthine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle lumen IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenosine deaminase
Names
adenosine aminohydrolase
NP_001258981.1
NP_001403804.1
NP_001403805.1
NP_031424.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272052.2NP_001258981.1  adenosine deaminase isoform 1

    See identical proteins and their annotated locations for NP_001258981.1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17015.1
    UniProtKB/Swiss-Prot
    P03958
    UniProtKB/TrEMBL
    Q4FJZ7, Q4FK28
    Conserved Domains (1) summary
    cd01320
    Location:8336
    ADA; Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in ...
  2. NM_001416875.1NP_001403804.1  adenosine deaminase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591490
  3. NM_001416876.1NP_001403805.1  adenosine deaminase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591490
  4. NM_007398.5NP_031424.1  adenosine deaminase isoform 1

    See identical proteins and their annotated locations for NP_031424.1

    Status: VALIDATED

    Source sequence(s)
    AL591490
    Consensus CDS
    CCDS17015.1
    UniProtKB/Swiss-Prot
    P03958
    UniProtKB/TrEMBL
    Q4FJZ7, Q4FK28
    Related
    ENSMUSP00000017841.4, ENSMUST00000017841.4
    Conserved Domains (1) summary
    cd01320
    Location:8336
    ADA; Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in ...

RNA

  1. NR_184399.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591490

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163565703..163592154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004937552.1 RNA Sequence