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Ifitm2 interferon induced transmembrane protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114709, updated on 2-Nov-2024

Summary

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Official Symbol
Ifitm2provided by RGD
Official Full Name
interferon induced transmembrane protein 2provided by RGD
Primary source
RGD:69332
See related
AllianceGenome:RGD:69332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ifitml; Ifitm3l
Summary
Involved in heart development. Predicted to be located in bounding membrane of organelle; cell junction; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in adenosquamous gallbladder carcinoma and gallbladder adenocarcinoma. Orthologous to several human genes including IFITM2 (interferon induced transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 972.6), Adrenal (RPKM 884.8) and 9 other tissues See more
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Genomic context

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See Ifitm2 in Genome Data Viewer
Location:
1q41
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205481168..205482348, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196051539..196052719, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213750219..213751399, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein-glucosylgalactosylhydroxylysine glucosidase Neighboring gene interferon induced transmembrane protein 5 Neighboring gene interferon induced transmembrane protein 1 Neighboring gene uncharacterized LOC120097360

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interferon-inducible genes in the rat adrenal gland and vascular smooth muscle cells. Daido H, et al. Mol Cell Endocrinol, 2003 Feb 28. PMID 12644301
  2. Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes. Lau SL, et al. J Cell Biochem, 2012 Mar. PMID 22021094, Free PMC Article
  3. IFITM proteins restrict viral membrane hemifusion. Li K, et al. PLoS Pathog, 2013 Jan. PMID 23358889, Free PMC Article
  4. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. Chan YK, et al. PLoS One, 2012. PMID 22479637, Free PMC Article
  5. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. Weidner JM, et al. J Virol, 2010 Dec. PMID 20943977, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC72804

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-alpha IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon-induced transmembrane protein 2
Names
interferon induced transmembrane protein 2 (1-8D)
interferon induced transmembrane protein, like
interferon-inducible protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030833.1 → NP_110460.1  interferon-induced transmembrane protein 2

    See identical proteins and their annotated locations for NP_110460.1

    Status: PROVISIONAL

    Source sequence(s)
    AF164040
    UniProtKB/TrEMBL
    F7EN36, Q9R175
    Conserved Domains (1) summary
    pfam04505
    Location:54 → 120
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205481168..205482348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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