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Cdc42bpb CDC42 binding protein kinase beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 113960, updated on 18-Sep-2024

Summary

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Official Symbol
Cdc42bpbprovided by RGD
Official Full Name
CDC42 binding protein kinase betaprovided by RGD
Primary source
RGD:621753
See related
EnsemblRapid:ENSRNOG00000009675 AllianceGenome:RGD:621753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity and small GTPase binding activity. Involved in actomyosin structure organization; cell migration; and protein phosphorylation. Located in actomyosin. Orthologous to human CDC42BPB (CDC42 binding protein kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 168.3), Adrenal (RPKM 163.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdc42bpb in Genome Data Viewer
Location:
6q32
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136154905..136241259, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130333712..130416631, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (135746743..135830144, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene Tnf receptor-associated factor 3 Neighboring gene amnion associated transmembrane protein Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. Heikkila T, et al. PLoS One, 2011. PMID 21949762, Free PMC Article
  2. Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. Leung T, et al. Mol Cell Biol, 1998 Jan. PMID 9418861, Free PMC Article
  3. A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. Tan I, et al. Cell, 2008 Oct 3. PMID 18854160
  4. Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. Lee ICJ, et al. J Biol Chem, 2014 Sep 26. PMID 25107909, Free PMC Article
  5. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Lant B, et al. Nat Commun, 2015 Mar 6. PMID 25743393

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actomyosin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actomyosin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK beta
Names
CDC42 binding protein kinase beta (DMPK-like)
Cdc42-binding protein kinase beta
DMPK-like beta
MRCK beta
myotonic dystrophy kinase-related CDC42-binding kinase beta
myotonic dystrophy protein kinase-like beta
NP_446072.2
XP_006240624.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053620.3 → NP_446072.2  serine/threonine-protein kinase MRCK beta

    See identical proteins and their annotated locations for NP_446072.2

    Status: VALIDATED

    Source sequence(s)
    AY277590, CB748377
    UniProtKB/Swiss-Prot
    O54875, Q7TT49
    UniProtKB/TrEMBL
    A6KBQ2, A6KBQ3
    Related
    ENSRNOP00000036487.2, ENSRNOT00000039059.5
    Conserved Domains (8) summary
    pfam08826
    Location:878 → 939
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:76 → 342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:1027 → 1076
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1086 → 1220
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05624
    Location:3 → 411
    STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
    pfam00780
    Location:1246 → 1512
    CNH; CNH domain
    pfam13868
    Location:419 → 786
    TPH; Trichohyalin-plectin-homology domain
    pfam15796
    Location:528 → 606
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    136154905..136241259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240562.5 → XP_006240624.1  serine/threonine-protein kinase MRCK beta isoform X1

    UniProtKB/TrEMBL
    A6KBQ2
    Related
    ENSRNOP00000108806.1, ENSRNOT00000157383.1
    Conserved Domains (8) summary
    pfam08826
    Location:878 → 939
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:76 → 342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:1044 → 1093
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1103 → 1237
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05624
    Location:3 → 411
    STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
    pfam00780
    Location:1263 → 1529
    CNH; CNH domain
    pfam13868
    Location:419 → 786
    TPH; Trichohyalin-plectin-homology domain
    pfam15796
    Location:528 → 606
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

RNA

  1. XR_005505433.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT49.1 GenPept UniProtKB/Swiss-Prot:Q7TT49

Gene LinkOut

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