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PLCD3 phospholipase C delta 3 [ Homo sapiens (human) ]

Gene ID: 113026, updated on 2-Nov-2024

Summary

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Official Symbol
PLCD3provided by HGNC
Official Full Name
phospholipase C delta 3provided by HGNC
Primary source
HGNC:HGNC:9061
See related
Ensembl:ENSG00000161714 MIM:608795; AllianceGenome:HGNC:9061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLC-delta-3
Summary
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 22.8), urinary bladder (RPKM 21.5) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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See PLCD3 in Genome Data Viewer
Location:
17q21.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45108959..45132515, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45962835..45986399, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43186327..43209882, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43074788-43075540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43080963-43081726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43083016-43083972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43085503-43086003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43089992-43090778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12268 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43096740-43096919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43112912-43113412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43113413-43113913 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43117423-43118057 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43118058-43118692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43118693-43119327 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43120482-43121367 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43121368-43122252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43124492-43125024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43125025-43125555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8608 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43137465-43138456 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43138457-43139448 Neighboring gene N-myristoyltransferase 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:43168092-43168593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43175496-43175996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43175997-43176497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43180894-43181394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43184227-43184728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43189298-43190163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43190164-43191028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43191895-43192759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43198136-43198673 Neighboring gene microRNA 6784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43220320-43221042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43221043-43221764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43222487-43223207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43224945-43225827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12277 Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43226945-43227500 Neighboring gene HEXIM2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43237877-43238492 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43238493-43239108 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43239109-43239724 Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene uncharacterized LOC105371795 Neighboring gene HEXIM P-TEFb complex subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling. Wang M, et al. BMC Cancer, 2023 Sep 29. PMID 37773107, Free PMC Article
  2. Gene expression analysis reveals novel altered genes in nasal polyps. Babeto E, et al. Mol Med Rep, 2010 May-Jun. PMID 21472267
  3. Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms. Zhou X, et al. Cancer Med, 2020 Feb. PMID 31808619, Free PMC Article
  4. Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway. Lin L, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Mar 26. PMID 33674820
  5. Downregulation of phospholipase C delta3 by cAMP and calcium. Lin FG, et al. Biochem Biophys Res Commun, 2001 Aug 17. PMID 11500033

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling.
    Title: PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling.
  2. Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression.
    Title: Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression.
  3. CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.
    Title: CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.
  4. Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway.
    Title: Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation, migration, and invasion of thyroid cancer cells via Hippo pathway.
  5. Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.
    Title: Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.
  6. Results identified an interaction between PLCD3 and FLOT2. Inhibition of PLCD3 expression impaired the malignant potential of nasopharyngeal carcinoma (NPC) cells, by restraining its growth, proliferation, mobility and migration. This study demonstrated that PLCD3 may be an oncogenic protein in NPC and that it plays an important role in the progression of NPC partially by interacting with Flot2.
    Title: PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells.
  7. PLCdelta3 regulates microvilli formation in enterocytes and the radial migration of neurons in the cerebral cortex of the developing brain. [review]
    Title: Physiological functions of phospholipase Cδ1 and phospholipase Cδ3.
  8. In mouse, Plcd1 and Plcd3 may act together in murine hair follicles.
    Title: Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.
  9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
  10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC71172

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
Names
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3
PLC delta3
phosphoinositide phospholipase C-delta-3
NP_588614.1
XP_011522555.1
XP_024306322.1
XP_054170882.1
XP_054170883.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133373.5 → NP_588614.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

    See identical proteins and their annotated locations for NP_588614.1

    Status: REVIEWED

    Source sequence(s)
    AC002117, AL834392, BC072384, BU621728, HY169731
    Consensus CDS
    CCDS74077.1
    UniProtKB/Swiss-Prot
    Q8N3E9, Q8TEC1, Q8TF37, Q96FL6
    Related
    ENSP00000479636.1, ENST00000619929.5
    Conserved Domains (7) summary
    cd00275
    Location:660 → 787
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08630
    Location:336 → 631
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    PLN02228
    Location:255 → 772
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:65 → 181
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:70 → 170
    PH; PH domain
    pfam09279
    Location:255 → 336
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam14788
    Location:201 → 250
    EF-hand_10; EF hand

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    45108959..45132515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450554.2 → XP_024306322.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

    Conserved Domains (4) summary
    cd00275
    Location:705 → 832
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08630
    Location:336 → 676
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    cd13363
    Location:65 → 181
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16218
    Location:186 → 324
    EFh_PI-PLCdelta3; EF-hand motif found in phosphoinositide phospholipase C delta 3 (PI-PLC-delta3)

  2. XM_011524253.4 → XP_011522555.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

    Conserved Domains (5) summary
    cd13363
    Location:65 → 181
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:70 → 170
    PH; PH domain
    pfam09279
    Location:255 → 336
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam14788
    Location:201 → 250
    EF-hand_10; EF hand
    cl14615
    Location:336 → 471
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    45962835..45986399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314907.1 → XP_054170882.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

  2. XM_054314908.1 → XP_054170883.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N3E9.3 GenPept UniProtKB/Swiss-Prot:Q8N3E9

Gene LinkOut

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