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Ifit1bl2 interferon induced protein with tetratricopeptide repeats 1B like 2 [ Mus musculus (house mouse) ]

Gene ID: 112419, updated on 2-Nov-2024

Summary

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Official Symbol
Ifit1bl2provided by MGI
Official Full Name
interferon induced protein with tetratricopeptide repeats 1B like 2provided by MGI
Primary source
MGI:MGI:2148249
See related
Ensembl:ENSMUSG00000067297 AllianceGenome:MGI:2148249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifit1b; 2010002M12Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to several human genes including IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 4.7), small intestine adult (RPKM 3.6) and 4 other tissues See more
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Genomic context

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See Ifit1bl2 in Genome Data Viewer
Location:
19 C1; 19 29.76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34594446..34618163, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34617046..34640827, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11027 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene STARR-positive B cell enhancer ABC_E11028 Neighboring gene interferon induced protein with tetratricpeptide repeats 1B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5698 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3B Neighboring gene calponin2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45998 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene STARR-positive B cell enhancer ABC_E9997 Neighboring gene STARR-seq mESC enhancer starr_46000 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 12 Neighboring gene 60S ribosomal protein L36a-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c. Mears HV, et al. J Biol Chem, 2020 Dec 18. PMID 33454014, Free PMC Article
  2. Interferon-induced Ifit proteins: their role in viral pathogenesis. Fensterl V, et al. J Virol, 2015 Mar. PMID 25428874, Free PMC Article
  3. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Diamond MS, et al. Nat Rev Immunol, 2013 Jan. PMID 23237964, Free PMC Article
  4. The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. Langlais D, et al. J Exp Med, 2016 Apr 4. PMID 27001747, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
    Title: Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon induced protein with tetratricopeptide repeats 1B like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362130.1 → NP_001349059.1  interferon induced protein with tetratricopeptide repeats 1B like 2

    Status: VALIDATED

    Source sequence(s)
    AC016791
    Consensus CDS
    CCDS29765.1
    UniProtKB/TrEMBL
    Q3U687
    Conserved Domains (2) summary
    sd00006
    Location:282 → 329
    TPR; TPR repeat [structural motif]
    cl26002
    Location:63 → 353
    TPR_11; TPR repeat

  2. NM_053217.3 → NP_444447.1  interferon induced protein with tetratricopeptide repeats 1B like 2

    See identical proteins and their annotated locations for NP_444447.1

    Status: VALIDATED

    Source sequence(s)
    AK136525, AK153247
    Consensus CDS
    CCDS29765.1
    UniProtKB/TrEMBL
    Q3U687
    Related
    ENSMUSP00000093816.3, ENSMUST00000087357.5
    Conserved Domains (2) summary
    sd00006
    Location:282 → 329
    TPR; TPR repeat [structural motif]
    cl26002
    Location:63 → 353
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34594446..34618163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250699.2 → XP_030106559.1  interferon induced protein with tetratricopeptide repeats 1B like 2 isoform X1

    Conserved Domains (3) summary
    TIGR02521
    Location:263 → 340
    type_IV_pilW; type IV pilus biogenesis/stability protein PilW
    TIGR02917
    Location:2 → 292
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:221 → 268
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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