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Kif22 kinesin family member 22 [ Mus musculus (house mouse) ]

Gene ID: 110033, updated on 2-Nov-2024

Summary

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Official Symbol
Kif22provided by MGI
Official Full Name
kinesin family member 22provided by MGI
Primary source
MGI:MGI:109233
See related
Ensembl:ENSMUSG00000030677 AllianceGenome:MGI:109233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kid; Kif22a
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; mitotic metaphase chromosome alignment; and sister chromatid cohesion. Located in chromatin and spindle. Is expressed in cerebral cortex ventricular layer; cortical plate; and inner cell mass. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 2. Orthologous to human KIF22 (kinesin family member 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 35.8), liver E14 (RPKM 33.5) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Kif22 in Genome Data Viewer
Location:
7 F3; 7 69.29 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126626901..126641639, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127027729..127042467, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene proline-rich transmembrane protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134167876-134168063 Neighboring gene predicted gene, 53372 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134170996-134171192 Neighboring gene STARR-seq mESC enhancer starr_20164 Neighboring gene MYC-associated zinc finger protein (purine-binding transcription factor) Neighboring gene STARR-positive B cell enhancer ABC_E9708 Neighboring gene zymogen granule protein 16 Neighboring gene STARR-positive B cell enhancer ABC_E8210 Neighboring gene predicted gene, 22747

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIF22 regulates mitosis and proliferation of chondrocyte cells. Kawaue H, et al. iScience, 2024 Jul 19. PMID 38989461, Free PMC Article
  2. The microtubule-binding and coiled-coil domains of Kid are required to turn off the polar ejection force at anaphase. Soeda S, et al. J Cell Sci, 2016 Oct 1. PMID 27550518
  3. Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Ohsugi M, et al. Cell, 2008 Mar 7. PMID 18329364
  4. The second microtubule-binding site of monomeric kid enhances the microtubule affinity. Shiroguchi K, et al. J Biol Chem, 2003 Jun 20. PMID 12692123
  5. The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Dickins RA, et al. Mol Cell Biol, 2002 Apr. PMID 11884614, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF22
Names
kinesin family member 22A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403623.1 → NP_001390552.1  kinesin-like protein KIF22 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122863

  2. NM_145588.2 → NP_663563.1  kinesin-like protein KIF22 isoform 1

    See identical proteins and their annotated locations for NP_663563.1

    Status: VALIDATED

    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS21855.1
    UniProtKB/Swiss-Prot
    O35232, Q3V300, Q99LC7
    Related
    ENSMUSP00000032915.7, ENSMUST00000032915.8
    Conserved Domains (3) summary
    smart00129
    Location:38 → 370
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01376
    Location:38 → 361
    KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
    pfam12836
    Location:591 → 641
    HHH_3; Helix-hairpin-helix motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126626901..126641639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507201.2 → XP_006507264.1  kinesin-like protein KIF22 isoform X1

    Conserved Domains (2) summary
    cd01376
    Location:38 → 361
    KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
    cl39090
    Location:591 → 641
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V300.2 GenPept UniProtKB/Swiss-Prot:Q3V300

Gene LinkOut

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