Otub1 OTU domain, ubiquitin aldehyde binding 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Otub1provided by MGI
Official Full Name: OTU domain, ubiquitin aldehyde binding 1provided by MGI
Primary source: MGI:MGI:2147616
See related: Ensembl:ENSMUSG00000024767 AllianceGenome:MGI:2147616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein-specific protease activity. Predicted to be involved in cellular response to DNA damage stimulus; negative regulation of nitrogen compound metabolic process; and protein K48-linked deubiquitination. Predicted to act upstream of or within protein deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including endocrine gland; genitourinary system; nervous system; oral epithelium; and sensory organ. Orthologous to human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 75.5), adrenal adult (RPKM 60.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.27 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (7175571..7183649, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7198206..7206284, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRbeta.
Title: Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ.
Deubiquitylating Enzyme OTUB1 Facilitates Neuronal Survival After Intracerebral Hemorrhage Via Inhibiting NF-kappaB-triggered Apoptotic Cascades.
Title: Deubiquitylating Enzyme OTUB1 Facilitates Neuronal Survival After Intracerebral Hemorrhage Via Inhibiting NF-κB-triggered Apoptotic Cascades.
The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the gamma-Subunit Gng2.
Title: The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.
OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2.
Title: OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2.
Partial otubain 1 deficiency compromises fetal well-being in allogeneic pregnancies despite no major changes in the dendritic cell and T cell compartment.
Title: Partial otubain 1 deficiency compromises fetal well-being in allogeneic pregnancies despite no major changes in the dendritic cell and T cell compartment.
ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1.
Title: ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1.
S-Nitrosylation of OTUB1 Alters Its Stability and Ubc13 Binding.
Title: S-Nitrosylation of OTUB1 Alters Its Stability and Ubc13 Binding.
OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways.
Title: OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways.
The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism.
Title: The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism.
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.
Title: OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237882

AI850305 (e-PCR)
- UniSTS:166122

RH142168 (e-PCR)
- UniSTS:231420

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deNEDDylase activity	ISO Inferred from Sequence Orthology more info
enables deNEDDylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein deubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin thioesterase OTUB1

Names: OTU domain-containing ubiquitin aldehyde-binding protein 1; deubiquitinating enzyme OTUB1; otubain 1; ubiquitin-specific-processing protease OTUB1

NP_598911.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.