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CCT8 chaperonin containing TCP1 subunit 8 [ Homo sapiens (human) ]

Gene ID: 10694, updated on 3-Nov-2024

Summary

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Official Symbol
CCT8provided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 8provided by HGNC
Primary source
HGNC:HGNC:1623
See related
Ensembl:ENSG00000156261 MIM:617786; AllianceGenome:HGNC:1623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cctq; PRED71; D21S246; C21orf112
Summary
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in adrenal (RPKM 57.9), lymph node (RPKM 57.3) and 25 other tissues See more
Orthologs
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Genomic context

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See CCT8 in Genome Data Viewer
Location:
21q21.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (29056326..29073648, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (27419768..27437088, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30428647..30445969, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18327 Neighboring gene RWD domain containing 2B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18328 Neighboring gene ubiquitin specific peptidase 16 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:30416252-30416450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18330 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:30445041-30445952 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:30445953-30446864 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:30447741-30448940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18333 Neighboring gene MAP3K7 C-terminal like Neighboring gene Sharpr-MPRA regulatory region 4059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13237 Neighboring gene NANOG hESC enhancer GRCh37_chr21:30506062-30506608 Neighboring gene ribosomal protein L12 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 14833 Neighboring gene uncharacterized LOC105372767 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. Noormohammadi A, et al. Nat Commun, 2016 Nov 28. PMID 27892468, Free PMC Article
  2. Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21. Yamazaki M, et al. DNA Res, 1995 Aug 31. PMID 8590283
  3. Overexpression of CCT8 and its significance for tumor cell proliferation, migration and invasion in glioma. Qiu X, et al. Pathol Res Pract, 2015 Oct. PMID 26304164
  4. Chaperonin-containing T‑complex protein 1 subunit 8 promotes cell migration and invasion in human esophageal squamous cell carcinoma by regulating α-actin and β-tubulin expression. Yang X, et al. Int J Oncol, 2018 Jun. PMID 29620162
  5. Glucose-regulated protein 94 mediates metastasis by CCT8 and the JNK pathway in hepatocellular carcinoma. Wei PL, et al. Tumour Biol, 2016 Jun. PMID 26718209

See all (322) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrated that CCT8 expression is widely upregulated in esophageal squamous cell carcinoma (ESCC), and enhanced the migration and invasion of ESCC cells, indicating that ectopic CCT8 expression contributes to the highly aggressive nature of ESCC probably by increasing alpha-actin and beta-tubulin expression.
    Title: Chaperonin-containing T‑complex protein 1 subunit 8 promotes cell migration and invasion in human esophageal squamous cell carcinoma by regulating α-actin and β-tubulin expression.
  2. Ectopic expression of CCT8 also ameliorates the age-associated demise of proteostasis and corrects proteostatic deficiencies in worm models of Huntington's disease.
    Title: Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.
  3. data suggest that the GRP94/CCT8/c-Jun/EMT signaling cascade might be a new therapeutic target for HCC
    Title: Glucose-regulated protein 94 mediates metastasis by CCT8 and the JNK pathway in hepatocellular carcinoma.
  4. showed that high CCT8 protein expression might be related to poor outcome of glioma
    Title: Overexpression of CCT8 and its significance for tumor cell proliferation, migration and invasion in glioma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with CCT8 PubMed
Pr55(Gag) gag Cellular biotinylated CCT8 chaperonin containing TCP1, subunit 8 (theta) protein is incorporated into HIV-1 Gag virus-like particles PubMed
Vif vif HIV-1 Vif interacts with CCT8 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone mediated protein folding independent of cofactor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein localization to Cajal body HMP PubMed 
involved_in positive regulation of telomerase RNA localization to Cajal body HMP PubMed 
acts_upstream_of positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
located_in cell body IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chaperonin-containing T-complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of chaperonin-containing T-complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  
part_of zona pellucida receptor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-complex protein 1 subunit theta
Names
CCT-theta
TCP-1-theta
chaperonin containing T-complex polypeptide 1 subunit 8
chaperonin containing TCP1, subunit 8 (theta)
renal carcinoma antigen NY-REN-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282907.2 → NP_001269836.1  T-complex protein 1 subunit theta isoform 2

    See identical proteins and their annotated locations for NP_001269836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and contains an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK293705, BC072001, BP248736, DB301557, DC298601
    Consensus CDS
    CCDS68181.1
    UniProtKB/TrEMBL
    Q53HU0
    Related
    ENSP00000486921.1, ENST00000626972.2
    Conserved Domains (1) summary
    TIGR02346
    Location:2 → 520
    chap_CCT_theta; T-complex protein 1, theta subunit

  2. NM_001282908.2 → NP_001269837.1  T-complex protein 1 subunit theta isoform 3

    See identical proteins and their annotated locations for NP_001269837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC012584, BP248736
    UniProtKB/TrEMBL
    Q53HU0, Q7Z759
    Related
    ENST00000470450.5
    Conserved Domains (2) summary
    pfam00118
    Location:1 → 477
    Cpn60_TCP1; TCP-1/cpn60 chaperonin family
    cl02777
    Location:1 → 488
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...

  3. NM_001282909.2 → NP_001269838.1  T-complex protein 1 subunit theta isoform 4

    See identical proteins and their annotated locations for NP_001269838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 4, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298801, BC072001, DB301557
    Consensus CDS
    CCDS68180.1
    UniProtKB/TrEMBL
    Q53HU0
    Related
    ENSP00000442730.1, ENST00000540844.5
    Conserved Domains (1) summary
    cl02777
    Location:5 → 466
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...

  4. NM_006585.4 → NP_006576.2  T-complex protein 1 subunit theta isoform 1

    See identical proteins and their annotated locations for NP_006576.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC072001
    Consensus CDS
    CCDS33528.1
    UniProtKB/Swiss-Prot
    A6NN54, B4DEM7, B4DQH4, P50990, Q4VBP8
    UniProtKB/TrEMBL
    Q53HU0
    Related
    ENSP00000286788.4, ENST00000286788.9
    Conserved Domains (1) summary
    TIGR02346
    Location:10 → 539
    chap_CCT_theta; T-complex protein 1, theta subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    29056326..29073648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440668.1 → XP_047296624.1  T-complex protein 1 subunit theta isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791813.1 Reference GRCh38.p14 PATCHES

    Range
    147060..164382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    27419768..27437088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50990.4 GenPept UniProtKB/Swiss-Prot:P50990

Gene LinkOut

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