U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abhd4 abhydrolase domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 105501, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Abhd4provided by MGI
Official Full Name
abhydrolase domain containing 4provided by MGI
Primary source
MGI:MGI:1915938
See related
Ensembl:ENSMUSG00000040997 AllianceGenome:MGI:1915938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abh4; 1110035H23Rik
Summary
Enables lysophospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Acts upstream of or within N-acylethanolamine metabolic process. Predicted to be active in lipid droplet and mitochondrion. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; and retina. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 181.0), testis adult (RPKM 84.5) and 17 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Abhd4 in Genome Data Viewer
Location:
14 C2; 14 27.71 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54491586..54506626)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54254129..54269169)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha chain Neighboring gene STARR-positive B cell enhancer ABC_E7311 Neighboring gene CapStarr-seq enhancers MGSCv37_chr14:54846812-54847013 and MGSCv37_chr14:54847102-54847395 Neighboring gene STARR-positive B cell enhancer ABC_E5435 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:54852981-54853251 Neighboring gene STARR-positive B cell enhancer ABC_E1168 Neighboring gene predicted gene 43305 Neighboring gene T cell receptor alpha constant Neighboring gene olfactory receptor family 6 subfamily E member 1 Neighboring gene defender against cell death 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Lee HC, et al. Biochemistry, 2015 Apr 21. PMID 25853435, Free PMC Article
  2. ABHD4-dependent developmental anoikis safeguards the embryonic brain. László ZI, et al. Nat Commun, 2020 Aug 31. PMID 32868797, Free PMC Article
  3. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. Simon GM, et al. J Biol Chem, 2006 Sep 8. PMID 16818490
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice.
    Title: ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice.
  2. These findings, taken together, designate ABHD4 as a principal regulator of N-acyl phospholipid metabolism in the mammalian nervous system.
    Title: ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system.
  3. Lysophospholipase/phospholipase B (EC 3.1.1.5) specific for N-acyl phosphatidylethanolamine (NAPE) suggesting a role in the biosynthesis of N-acyl ethanolamines including the endocannabinoid anandamide.
    Title: Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lysophosphatidic acid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within N-acylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
(Lyso)-N-acylphosphatidylethanolamine lipase
Names
abhydrolase domain-containing protein 4
alpha/beta hydrolase domain-containing protein 4
alpha/beta-hydrolase 4
lyso-N-acylphosphatidylethanolamine lipase
protein ABHD4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205181.1 → NP_001192110.1  (Lyso)-N-acylphosphatidylethanolamine lipase isoform 2

    See identical proteins and their annotated locations for NP_001192110.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK030250, AK049366, CN713874, CT573018
    Consensus CDS
    CCDS56955.1
    UniProtKB/TrEMBL
    Q3U7M5, Q8C0M2
    Related
    ENSMUSP00000137214.2, ENSMUST00000180359.8
    Conserved Domains (1) summary
    PLN02894
    Location:32 → 314
    PLN02894; hydrolase, alpha/beta fold family protein

  2. NM_134076.3 → NP_598837.3  (Lyso)-N-acylphosphatidylethanolamine lipase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    CT573018
    Consensus CDS
    CCDS56954.1
    UniProtKB/Swiss-Prot
    Q8VD66
    UniProtKB/TrEMBL
    Q3U7M5
    Related
    ENSMUSP00000044134.9, ENSMUST00000041197.13
    Conserved Domains (1) summary
    PLN02894
    Location:11 → 338
    PLN02894; hydrolase, alpha/beta fold family protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54491586..54506626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518367.4 → XP_006518430.1  (Lyso)-N-acylphosphatidylethanolamine lipase isoform X1

    See identical proteins and their annotated locations for XP_006518430.1

    UniProtKB/TrEMBL
    Q3U7M5, Q8C0M2
    Conserved Domains (1) summary
    PLN02894
    Location:32 → 314
    PLN02894; hydrolase, alpha/beta fold family protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VD66.1 GenPept UniProtKB/Swiss-Prot:Q8VD66

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous