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Rpn1 ribophorin I [ Mus musculus (house mouse) ]

Gene ID: 103963, updated on 2-Nov-2024

Summary

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Official Symbol
Rpn1provided by MGI
Official Full Name
ribophorin Iprovided by MGI
Primary source
MGI:MGI:98084
See related
Ensembl:ENSMUSG00000030062 AllianceGenome:MGI:98084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpn-1; D6Wsu137e
Summary
Predicted to be involved in protein N-linked glycosylation via asparagine. Located in endoplasmic reticulum membrane and rough endoplasmic reticulum. Part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Orthologous to human RPN1 (ribophorin I). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 91.8), ovary adult (RPKM 79.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpn1 in Genome Data Viewer
Location:
6 D1; 6 39.13 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88061455..88082286)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88084473..88105304)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34872 Neighboring gene RAB7, member RAS oncogene family Neighboring gene predicted gene, 38855 Neighboring gene STARR-seq mESC enhancer starr_16574 Neighboring gene STARR-positive B cell enhancer ABC_E2195 Neighboring gene microRNA 6376 Neighboring gene predicted gene, 53293 Neighboring gene Gata2R1 erythroid cis-regulatory module Neighboring gene stem and progenitor enriched required for hematopoietic differentiation Neighboring gene predicted gene, 38856

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system. Khandekar M, et al. Mol Cell Biol, 2004 Dec. PMID 15542836, Free PMC Article
  2. TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation. Graham DB, et al. Cell Rep, 2016 Dec 13. PMID 27974209, Free PMC Article
  3. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Harding HP, et al. Nature, 1999 Jan 21. PMID 9930704
  4. NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly. Kweon HJ, et al. Cell Rep, 2020 Aug 11. PMID 32783947
  5. Determination of downstream targets of FGF signalling using gene trap and cDNA subtractive approaches. Tateossian H, et al. Exp Cell Res, 2004 Jan 1. PMID 14720510

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Names
RPN-I
dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit
ribophorin-1
NP_598694.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133933.4 → NP_598694.3  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor

    See identical proteins and their annotated locations for NP_598694.3

    Status: VALIDATED

    Source sequence(s)
    AK029923, BC085483, BY308146
    Consensus CDS
    CCDS20332.1
    UniProtKB/Swiss-Prot
    Q3U985, Q91YQ5
    UniProtKB/TrEMBL
    Q3U900, Q5RKP4, Q8BMR3
    Related
    ENSMUSP00000032143.7, ENSMUST00000032143.8
    Conserved Domains (2) summary
    pfam04597
    Location:34 → 458
    Ribophorin_I; Ribophorin I
    pfam10482
    Location:520 → 590
    CtIP_N; Tumour-suppressor protein CtIP N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88061455..88082286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YQ5.1 GenPept UniProtKB/Swiss-Prot:Q91YQ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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