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HIF1A hypoxia inducible factor 1 subunit alpha [ Saimiri boliviensis (Bolivian squirrel monkey) ]

Gene ID: 101044689, updated on 8-Mar-2024

Summary

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Gene symbol
HIF1A
Gene description
hypoxia inducible factor 1 subunit alpha
See related
EnsemblRapid:ENSSBOG00000029024
Gene type
protein coding
RefSeq status
MODEL
Organism
Saimiri boliviensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Saimiriinae; Saimiri
Orthologs
human mouse all
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Genomic context

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See HIF1A in Genome Data Viewer
Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
102 current BCM_Sbol_2.0 (GCF_016699345.1) Unplaced Scaffold NW_024100921.1 (66905101..66963102)

NW_024100921.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 30B Neighboring gene protein kinase C eta Neighboring gene transcription initiation factor TFIID subunit 13-like Neighboring gene small nuclear RNA activating complex polypeptide 1 Neighboring gene cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_024100921 Unplaced Scaffold Reference BCM_Sbol_2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hypoxia-inducible factor 1-alpha
Names
hypoxia inducible factor 1 alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Saimiri boliviensis Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BCM_Sbol_2.0 Primary Assembly

Genomic

  1. NW_024100921.1 Reference BCM_Sbol_2.0 Primary Assembly

    Range
    66905101..66963102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003924408.3 → XP_003924457.1  hypoxia-inducible factor 1-alpha isoform X2

    UniProtKB/TrEMBL
    A0A2K6U1D8, A0A2K6U1F9
    Conserved Domains (6) summary
    smart00091
    Location:93 → 148
    PAS; PAS domain
    cd00083
    Location:15 → 68
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:239 → 338
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:254 → 339
    PAS_3; PAS fold
    pfam08778
    Location:789 → 825
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:551 → 581
    HIF-1; Hypoxia-inducible factor-1

  2. XM_003924409.3 → XP_003924458.1  hypoxia-inducible factor 1-alpha isoform X4

    UniProtKB/TrEMBL
    A0A2K6U1F9, A0A2K6U1J2
    Related
    ENSSBOP00000025753.2, ENSSBOT00000042621.2
    Conserved Domains (5) summary
    smart00091
    Location:93 → 148
    PAS; PAS domain
    cd00083
    Location:15 → 68
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:239 → 338
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:254 → 339
    PAS_3; PAS fold
    pfam11413
    Location:551 → 581
    HIF-1; Hypoxia-inducible factor-1

  3. XM_010335137.2 → XP_010333439.1  hypoxia-inducible factor 1-alpha isoform X1

    UniProtKB/TrEMBL
    A0A2K6U1F9
    Related
    ENSSBOP00000025744.2, ENSSBOT00000042613.2
    Conserved Domains (6) summary
    smart00091
    Location:94 → 149
    PAS; PAS domain
    cd00083
    Location:16 → 69
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:240 → 339
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:255 → 340
    PAS_3; PAS fold
    pfam08778
    Location:790 → 826
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:552 → 582
    HIF-1; Hypoxia-inducible factor-1

  4. XM_010335138.2 → XP_010333440.1  hypoxia-inducible factor 1-alpha isoform X3

    UniProtKB/TrEMBL
    A0A2K6U1F9
    Conserved Domains (5) summary
    smart00091
    Location:94 → 149
    PAS; PAS domain
    cd00083
    Location:16 → 69
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:240 → 339
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:255 → 340
    PAS_3; PAS fold
    pfam11413
    Location:552 → 582
    HIF-1; Hypoxia-inducible factor-1
Nucleotide Protein
Heading Accession and Version

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