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MYCN MYCN proto-oncogene, bHLH transcription factor [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100454633, updated on 26-Mar-2024

Summary

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Gene symbol
MYCN
Gene description
MYCN proto-oncogene, bHLH transcription factor
Locus tag
CR201_G0022656
See related
Ensembl:ENSPPYG00000012635
Gene type
protein coding
RefSeq status
MODEL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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See MYCN in Genome Data Viewer
Location:
chromosome: 12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 12 NC_071997.2 (116887331..116893078, complement)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 2A NC_071986.1 (113437397..113443167, complement)

Chromosome 12 - NC_071997.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC129057755 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC112132100 Neighboring gene uncharacterized LOC103889897 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
N-myc proto-oncogene protein
Names
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_071997.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    116887331..116893078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009237532.4 → XP_009235807.1  N-myc proto-oncogene protein isoform X2

    See identical proteins and their annotated locations for XP_009235807.1

    UniProtKB/TrEMBL
    A0A2J8V478
    Conserved Domains (2) summary
    cd11456
    Location:167 → 253
    bHLHzip_N-Myc_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins
    pfam01056
    Location:66 → 161
    Myc_N; Myc amino-terminal region

  2. XM_024242770.3 → XP_024098538.1  N-myc proto-oncogene protein isoform X1

    UniProtKB/TrEMBL
    A0A2J8V487, A0A6D2XTM2, H2P6X2
    Related
    ENSPPYP00000014107.1
    Conserved Domains (2) summary
    cd00083
    Location:379 → 438
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:10 → 372
    Myc_N; Myc amino-terminal region
Nucleotide Protein
Heading Accession and Version

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