Fbxw7 F-box and WD repeat domain containing 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fbxw7provided by RGD
Full Name: F-box and WD repeat domain containing 7provided by RGD
Primary source: RGD:2321145
See related: EnsemblRapid:ENSRNOG00000010889 AllianceGenome:RGD:2321145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fbw7
Summary: Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of intracellular signal transduction; and positive regulation of protein metabolic process. Predicted to act upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 232.9), Heart (RPKM 101.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (172447738..172609591)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (170149706..170311536)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (184230191..184309805, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lncRNA DLX6-AS1 Promotes Myocardial Ischemia-Reperfusion Injury through Mediating the miR-204-5p/FBXW7 Axis.
Title: lncRNA DLX6-AS1 Promotes Myocardial Ischemia-Reperfusion Injury through Mediating the miR-204-5p/FBXW7 Axis.
FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition.
Title: FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition.
F-box and WD repeat domain-containing 7 (FBXW7) mediates the hypoxia inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) signaling pathway to affect hypoxic-ischemic brain damage in neonatal rats.
Title: F-box and WD repeat domain-containing 7 (FBXW7) mediates the hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway to affect hypoxic-ischemic brain damage in neonatal rats.
Calpain-mediated cleavage of Fbxw7 during excitotoxicity.
Title: Calpain-mediated cleavage of Fbxw7 during excitotoxicity.
Fbw7 participates in oxidative stress-induced myocardial cell injury via interacting with Mcl1.
Title: E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1.

Submit: New GeneRIF Correction

General gene information

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Markers

Fbxw7 (e-PCR), detects polymorphism
- UniSTS:498235

D2Rat119 (e-PCR), detects polymorphism
- UniSTS:118660

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphothreonine residue binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin recycling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box/WD repeat-containing protein 7

Names: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419528.2 → NP_001406457.1 F-box/WD repeat-containing protein 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

D3Z902

Related

ENSRNOP00000050193.4, ENSRNOT00000052051.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

172447738..172609591

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281082.1 → XP_063137152.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/Swiss-Prot

D3Z902
XM_039103741.2 → XP_038959669.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/Swiss-Prot

D3Z902

Conserved Domains (3) summary

cd00200
Location:380 → 656

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:390 → 425

7WD40; WD40 repeat [structural motif]

pfam12937
Location:287 → 331

F-box-like
XM_039103743.2 → XP_038959671.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/Swiss-Prot

D3Z902

Conserved Domains (3) summary

cd00200
Location:380 → 656

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:390 → 425

7WD40; WD40 repeat [structural motif]

pfam12937
Location:287 → 331

F-box-like
XM_039103739.2 → XP_038959667.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/Swiss-Prot

D3Z902

Conserved Domains (3) summary

cd00200
Location:380 → 656

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:390 → 425

7WD40; WD40 repeat [structural motif]

pfam12937
Location:287 → 331

F-box-like
XM_039103742.2 → XP_038959670.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/Swiss-Prot

D3Z902

Conserved Domains (3) summary

cd00200
Location:380 → 656

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:390 → 425

7WD40; WD40 repeat [structural motif]

pfam12937
Location:287 → 331

F-box-like
XM_039103744.2 → XP_038959672.1 F-box/WD repeat-containing protein 7 isoform X2

UniProtKB/Swiss-Prot

D3Z902

Conserved Domains (3) summary

cd00200
Location:380 → 656

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:390 → 425

7WD40; WD40 repeat [structural motif]

pfam12937
Location:287 → 331

F-box-like
XM_039103738.2 → XP_038959666.1 F-box/WD repeat-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0A8I6AED9

Related

ENSRNOP00000090758.1, ENSRNOT00000116921.2

Conserved Domains (3) summary

cd00200
Location:349 → 625

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:359 → 394

7WD40; WD40 repeat [structural motif]

pfam12937
Location:256 → 300

F-box-like
XM_006232555.5 → XP_006232617.1 F-box/WD repeat-containing protein 7 isoform X4

UniProtKB/TrEMBL

A0A0G2K979

Related

ENSRNOP00000074892.1, ENSRNOT00000081678.3

Conserved Domains (4) summary

COG2319
Location:251 → 574

WD40; WD40 repeat [General function prediction only]

cd00200
Location:256 → 532

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12937
Location:163 → 207

F-box-like; F-box-like

sd00039
Location:266 → 301

7WD40; WD40 repeat [structural motif]
XM_003749311.6 → XP_003749359.1 F-box/WD repeat-containing protein 7 isoform X3

UniProtKB/TrEMBL

D3ZQU4

Related

ENSRNOP00000015280.4, ENSRNOT00000015279.7

Conserved Domains (3) summary

cd00200
Location:296 → 572

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:306 → 341

7WD40; WD40 repeat [structural motif]

pfam12937
Location:203 → 247

F-box-like