PGR progesterone receptor [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: PGR
Gene description: progesterone receptor
See related: Ensembl:ENSOCUG00000014693
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	1	NC_067374.1 (129531414..129603219)

Chromosome 1 - NC_067374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067374.1 Chromosome 1 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PR activation around the time of mating and a post-mating decline in ovarian estradiol secretion and/or estradiol responsiveness act in parallel to terminate estrus in this species.
Title: Relevance of mating-associated stimuli, ovulation, and the progesterone receptor for the post-coital inhibition of estrous behavior in the female rabbit.
Differential time course and tissue specific immunoreactivity for PR in the uterus of the rabbit in two progestational conditions.
Title: Progesterone receptor immunoreactivity differs in the uterus of pseudopregnant and medroxyprogesterone acetate-treated rabbits.
expression differences among PGR genotypes in oviduct and uterus and when differences appear during gestation
Title: Expression of progesterone receptor related to the polymorphism in the PGR gene in the rabbit reproductive tract.
The wide distribution of PR mRNA in the rabbit brain suggests that progesterone through PR activation is involved in several functions apart from reproductive behavior in rabbits, and that PR expression is up-regulated by estradiol in the rabbit brain.
Title: Progesterone receptor mRNA expression and distribution in the female rabbit brain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: progesterone receptor

Names: PR; nuclear receptor subfamily 3 group C member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082267.1 → NP_001075736.1 progesterone receptor

See identical proteins and their annotated locations for NP_001075736.1

Status: PROVISIONAL

Source sequence(s)

M14547

UniProtKB/Swiss-Prot

P06186

UniProtKB/TrEMBL

A0A5F9CB18

Related

ENSOCUP00000012634.3, ENSOCUT00000014695.4

Conserved Domains (3) summary

cd07074
Location:683 → 930

NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor

cd07172
Location:564 → 641

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02161
Location:1 → 565

Prog_receptor; Progesterone receptor