NR1I2 nuclear receptor subfamily 1 group I member 2 [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: NR1I2
Gene description: nuclear receptor subfamily 1 group I member 2
See related: Ensembl:ENSOCUG00000006125
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as: PXR
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	14	NC_067387.1 (100042890..100075344, complement)

Chromosome 14 - NC_067387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067387.1 Chromosome 14 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nuclear receptor subfamily 1 group I member 2

Names: pregnane x receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082067.2 → NP_001075536.1 nuclear receptor subfamily 1 group I member 2

See identical proteins and their annotated locations for NP_001075536.1

Status: PROVISIONAL

Source sequence(s)

AF182217

UniProtKB/TrEMBL

A0A5K1UQE6, G1SQD9, Q9TU02

Related

ENSOCUP00000005307.4, ENSOCUT00000006124.4

Conserved Domains (2) summary

cd06934
Location:120 → 405

NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor

cl02596
Location:18 → 104

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers