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PPARD peroxisome proliferator activated receptor delta [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008615, updated on 8-Mar-2024

Summary

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Gene symbol
PPARD
Gene description
peroxisome proliferator activated receptor delta
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
PPAR-D/B
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See PPARD in Genome Data Viewer
Location:
chromosome: 12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 12 NC_067385.1 (130264174..130276989, complement)

Chromosome 12 - NC_067385.1Genomic Context describing neighboring genes Neighboring gene TEA domain transcription factor 3 Neighboring gene ribosomal protein L10a Neighboring gene FA complementation group E Neighboring gene uncharacterized LOC127493048 Neighboring gene DEF6 guanine nucleotide exchange factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067385.1 Chromosome 12 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hypothyroidism affects lipid and glycogen content and peroxisome proliferator-activated receptor δ expression in the ovary of the rabbit. Rodríguez-Castelán J, et al. Reprod Fertil Dev, 2018 Oct. PMID 29720336
  2. Cloning and function of rabbit peroxisome proliferator-activated receptor delta/beta in mature osteoclasts. Mano H, et al. J Biol Chem, 2000 Mar 17. PMID 10713135
  3. Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions. Han YM, et al. Biomed Res Int, 2020. PMID 32258142, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARdelta-AMPK-PGC-1alpha Pathway in Dyslipidemic Conditions.
    Title: Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions.
  2. Hypothyroidism increased total cholesterol and glycogen content, but reduced triacylglycerol content in the ovary. This was accompanied by a reduction in the expression of PLIN-A, changes in the presence of granules containing oxidative lipids and low PPARdelta expression. The results suggest that hypothyroidism modifies the content and signalling of lipids in the ovary, possibly affecting follicle maturation.
    Title: Hypothyroidism affects lipid and glycogen content and peroxisome proliferator-activated receptor δ expression in the ovary of the rabbit.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peroxisome proliferator-activated receptor delta
Names
peroxisome proliferator activated receptor delta/beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082000.1 → NP_001075469.1  peroxisome proliferator-activated receptor delta

    See identical proteins and their annotated locations for NP_001075469.1

    Status: PROVISIONAL

    Source sequence(s)
    AB033614
    UniProtKB/TrEMBL
    G1STN7, Q9N2H4
    Conserved Domains (2) summary
    cd06932
    Location:173 → 440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73 → 156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067385.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    130264174..130276989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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