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    KLF5 KLF transcription factor 5 [ Homo sapiens (human) ]

    Gene ID: 688, updated on 6-May-2024

    Summary

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    Official Symbol
    KLF5provided by HGNC
    Official Full Name
    KLF transcription factor 5provided by HGNC
    Primary source
    HGNC:HGNC:6349
    See related
    Ensembl:ENSG00000102554 MIM:602903; AllianceGenome:HGNC:6349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKLF; IKLF; BTEB2
    Summary
    This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
    Expression
    Broad expression in skin (RPKM 92.1), esophagus (RPKM 91.6) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    13q22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (73054976..73077538)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (72276491..72299055)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73629114..73651676)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73509249-73509443 Neighboring gene NANOG hESC enhancer GRCh37_chr13:73534622-73535123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73610339-73611015 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:73612066-73612896 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5398 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73648866-73649672 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73649673-73650478 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:73663997-73665196 Neighboring gene fatty acid binding protein 5 pseudogene 1 Neighboring gene RNA, U6 small nuclear 66, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency. Ai Z, et al. Cell Rep, 2022 Aug 23. PMID 36001968
    2. LMP2A inhibits the expression of KLF5 through the mTORC1 pathway in EBV-associated gastric carcinoma. Liu D, et al. Virus Res, 2022 Jul 2. PMID 35500764
    3. KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response. Shen X, et al. Cell Death Dis, 2022 Apr 5. PMID 35379798, Free PMC Article
    4. Simvastatin treatment promotes proliferation of human dental pulp stem cells via modulating PI3K/AKT/miR-9/KLF5 signalling pathway. Wang JH, et al. J Cell Mol Med, 2021 Dec. PMID 34799978, Free PMC Article
    5. Krüppel-like factor (KLF)5: An emerging foe of cardiovascular health. Palioura D, et al. J Mol Cell Cardiol, 2022 Feb. PMID 34653523, Free PMC Article

    See all (273) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.
      Title: Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.
    2. KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43.
      Title: KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43.
    3. Ubiquitin specific peptidase 38 epigenetically regulates KLF transcription factor 5 to augment malignant progression of lung adenocarcinoma.
      Title: Ubiquitin specific peptidase 38 epigenetically regulates KLF transcription factor 5 to augment malignant progression of lung adenocarcinoma.
    4. Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p.
      Title: Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p.
    5. [Overexpression of tuftelin and KLF-5 and its clinicopathological features in hepatitis B virus-related hepatocellular carcinoma].
      Title: [Overexpression of tuftelin and KLF-5 and its clinicopathological features in hepatitis B virus-related hepatocellular carcinoma].
    6. KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1.
      Title: KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1.
    7. Suppression of KLF5 basal expression in oral carcinoma-derived cells through three intact CREB1-binding sites in the silencer region.
      Title: Suppression of KLF5 basal expression in oral carcinoma-derived cells through three intact CREB1-binding sites in the silencer region.
    8. Circ_0068481 Affects the Human Pulmonary Artery Smooth Muscle Cells' Progression by miR-361-3p/KLF5 Axis.
      Title: Circ_0068481 Affects the Human Pulmonary Artery Smooth Muscle Cells' Progression by miR-361-3p/KLF5 Axis.
    9. KLF5/MDM2 Axis Modulates Oxidative Stress and Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells: The Role in Diabetic Cataract.
      Title: KLF5/MDM2 Axis Modulates Oxidative Stress and Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells: The Role in Diabetic Cataract.
    10. KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer.
      Title: KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (212)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of Kruppel-like factor 5 (KLF5) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables MRF binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling via exosome IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intestinal epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microvillus assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myotube differentiation involved in skeletal muscle regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of miRNA transcription IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by transcription factor localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microvillus assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in satellite cell activation involved in skeletal muscle regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal muscle satellite cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 5
    Names
    (intestinal Kruppel-like factor
    BTE-binding protein 2
    GC box binding protein 2
    Kruppel like factor 5
    Kruppel-like factor 5 (intestinal)
    basic transcription element binding protein 2
    colon krueppel-like factor
    colon kruppel-like factor
    epididymis secretory sperm binding protein
    intestinal-enriched krueppel-like factor
    intestinal-enriched kruppel-like factor
    transcription factor BTEB2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286818.2 → NP_001273747.1  Krueppel-like factor 5 isoform 2

      See identical proteins and their annotated locations for NP_001273747.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as tKLF5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AF132818, AK131397, AK302280, BM982025
      Consensus CDS
      CCDS66562.1
      UniProtKB/TrEMBL
      B4E2I1
      Related
      ENSP00000440407.1, ENST00000539231.5
      Conserved Domains (3) summary
      COG5048
      Location:268 → 342
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:328 → 353
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001730.5 → NP_001721.2  Krueppel-like factor 5 isoform 1

      See identical proteins and their annotated locations for NP_001721.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF132818, AK131397, BC007695, BC014302, BM982025
      Consensus CDS
      CCDS9448.1
      UniProtKB/Swiss-Prot
      A2TJX0, L0R3U5, L0R4T9, Q13887, Q9UHP8
      UniProtKB/TrEMBL
      A0A0A0N0M4, Q5T6X2
      Related
      ENSP00000366915.4, ENST00000377687.6
      Conserved Domains (3) summary
      COG5048
      Location:359 → 433
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:378 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:433 → 455
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      73054976..73077538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430553.1 → XP_047286509.1  Krueppel-like factor 5 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      72276491..72299055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374881.1 → XP_054230856.1  Krueppel-like factor 5 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13887.2 GenPept UniProtKB/Swiss-Prot:Q13887

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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