Dcp-1 Death caspase-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dcp-1provided by FlyBase
Official Full Name: Death caspase-1provided by FlyBase
Primary source: FLYBASE:FBgn0010501
Locus tag: Dmel_CG5370
See related: AllianceGenome:FB:FBgn0010501
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ccp1; cDcp; cDcp-1; CG5370; dcp-1; DCp-1; DCP-1; dcp1; Dcp1; DCP1; Dmel\CG5370; l(2)01862; l(2)02132
Summary: Enables BIR domain binding activity and cysteine-type endopeptidase activity involved in execution phase of apoptosis. Involved in several processes, including negative regulation of cell communication; neuron remodeling; and nurse cell apoptotic process. Located in mitochondrial matrix; neuronal cell body; and neuronal ribonucleoprotein granule. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; clypeo-labral primordium; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and neurodegenerative disease (multiple). Orthologous to human CASP3 (caspase 3) and CASP7 (caspase 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 59E3-59E3; 2-103 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23551313..23553547)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19438836..19441070)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis.
Title: Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis.
drICE and dcp-1 function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE but not dcp-1, but required drICE and dcp-1 when drICE activity was reduced via hypomorphic mutation.
Title: The role of the effector caspases drICE and dcp-1 for cell death and corpse clearance in the developing optic lobe in Drosophila.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1, and ice
Title: Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis.
Autophagy suppresses Dcp-1-mediated apoptotic cell death, whereas Dcp-1 positively regulates autophagy, possibly through feedback regulation.
Title: A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1, indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Title: piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline.
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.
Title: Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.
A double-mutant analysis between drICE and death caspase-1 (dcp-1), another effector caspase, reveals that some cells (type I) strictly require drICE for apoptosis, whereas other cells (type II) require either drICE or dcp-1.
Title: The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila.
novel characteristic morphological features of egg chambers lacking both dcp-1 and pita functions in the germline cells; suggested an essential role of dcp-1 and/or pita during mid-oogenesis
Title: Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0623 (e-PCR)
- UniSTS:50079

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables BIR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nurse cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: death caspase-1

Names: CG5370-PA; Dcp-1-PA; caspase; caspase 1; caspase-1; death caspase 1

NP_476974.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23551313..23553547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057626.4 → NP_476974.1 death caspase-1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476974.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02002, Q9W1N0

Related

FBpp0071971

Conserved Domains (1) summary

smart00115
Location:71 → 313

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues