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    ABCC1 multidrug resistance-associated protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839920, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCC1
    Official Full Name
    multidrug resistance-associated protein 1
    Primary source
    TAIR:AT1G30400
    Locus tag
    AT1G30400
    See related
    Araport:AT1G30400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana ATP-binding cassette C1; ARABIDOPSIS THALIANA MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; ATABCC1; ATMRP1; ATP-binding cassette C1; EST1; GLUTATHIONE S-CONJUGATE TRANSPORTING ATPASE; MRP1; multidrug resistance-associated protein 1; T4K22.12; T4K22_12
    Summary
    glutathione S-conjugate transporting ATPase (AtMRP1) mRNA. An ABCC-type arsenite-phytochelatin transporter. The expression of this gene is upregulated by herbicide safeners such as benoxacor and fenclorim.
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    Genomic context

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    See ABCC1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    28
    Sequence:
    Chromosome: 1; NC_003070.9 (10727317..10738092)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene photosystem I subunit K Neighboring gene multidrug resistance-associated protein 13 Neighboring gene multidrug resistance-associated protein 12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of amino acid residues important for the arsenic resistance function of Arabidopsis ABCC1. Zhang J, et al. FEBS Lett, 2017 Feb. PMID 28130831
    2. AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and functional definition of a plant ATP-binding cassette transporter gene. Lu YP, et al. Proc Natl Acad Sci U S A, 1997 Jul 22. PMID 9223346, Free PMC Article
    3. Plant Vacuolar ATP-binding Cassette Transporters That Translocate Folates and Antifolates in Vitro and Contribute to Antifolate Tolerance in Vivo. Raichaudhuri A, et al. J Biol Chem, 2009 Mar 27. PMID 19136566, Free PMC Article
    4. Arabidopsis thaliana MRP1 (AtABCC1) nucleotide binding domain contributes to arsenic stress tolerance with serine triad phosphorylation. Raichaudhuri A. Plant Physiol Biochem, 2016 Nov. PMID 27428365
    5. Vacuolar transport of abscisic acid glucosyl ester is mediated by ATP-binding cassette and proton-antiport mechanisms in Arabidopsis. Burla B, et al. Plant Physiol, 2013 Nov. PMID 24028845, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transport of acylated anthocyanins by the Arabidopsis ATP-binding cassette transporters AtABCC1, AtABCC2, and AtABCC14.
      Title: Transport of acylated anthocyanins by the Arabidopsis ATP-binding cassette transporters AtABCC1, AtABCC2, and AtABCC14.
    2. Data indicate that phosphorylation of serine Ser846 is required for the arsenic (As) resistance function of ATP-Binding Cassette (ABC) transporter ABCC1 (AtABCC1).
      Title: Identification of amino acid residues important for the arsenic resistance function of Arabidopsis ABCC1.
    3. MRP1 is important for vacuolar accumulation of antifolates as well as tolerance against arsenic, both of which involved phosphorylation in the serine triads at the C terminal nucleotide binding domain of MRP1.
      Title: Arabidopsis thaliana MRP1 (AtABCC1) nucleotide binding domain contributes to arsenic stress tolerance with serine triad phosphorylation.
    4. AtABCC1 and AtABCC2 are important vacuolar transporters that confer tolerance to cadmium and mercury, in addition to their role in arsenic detoxification.
      Title: The phytochelatin transporters AtABCC1 and AtABCC2 mediate tolerance to cadmium and mercury.
    5. Data show that the ABC transporters AtABCC1 (At1g30400) and AtABCC2 (AT2G34660) exhibit abscisic acid glucosyl ester (ABA-GE) transport activity in vitro.
      Title: Vacuolar transport of abscisic acid glucosyl ester is mediated by ATP-binding cassette and proton-antiport mechanisms in Arabidopsis.
    6. AtABCC1 and AtABCC2 are the long-sought and major vacuolar phytochelatin transporters
      Title: Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters.
    7. atmrp1 knock-out mutants are more sensitive than wild-type plants to growth retardation by nanomolar concentrations of MTX, and this is associated with impaired vacuolar antifolate sequestration.
      Title: Plant Vacuolar ATP-binding Cassette Transporters That Translocate Folates and Antifolates in Vitro and Contribute to Antifolate Tolerance in Vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036039.2
    NM_102777.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type phytochelatin transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type xenobiotic transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled arsenite transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within (+)-abscisic acid D-glucopyranosyl ester transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within arsenite transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xenobiotic transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in vacuolar membrane HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    multidrug resistance-associated protein 1
    NP_001031116.1
    • ARABIDOPSIS THALIANA MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (ATMRP1); FUNCTIONS IN: xenobiotic-transporting ATPase activity, ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: response to cyclopentenone; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 2 (TAIR:AT2G34660.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_174329.1
    • multidrug resistance-associated protein 1 (MRP1); FUNCTIONS IN: xenobiotic-transporting ATPase activity, ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: response to cyclopentenone; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 2 (TAIR:AT2G34660.2); Has 677063 Blast hits to 355607 proteins in 3971 species: Archae - 12123; Bacteria - 549360; Metazoa - 12555; Fungi - 7909; Plants - 6149; Viruses - 21; Other Eukaryotes - 88946 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10727317..10738092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102777.3 → NP_174329.1  multidrug resistance-associated protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24635, Q8RX76, Q9C8G9, Q9SAQ1
      UniProtKB/TrEMBL
      A0A178WBV0, A0A5S9WDU0, A0A7G2DWV7
      Conserved Domains (1) summary
      PLN03130
      Location:1 → 1622
      PLN03130; ABC transporter C family member; Provisional

    2. NM_001036039.2 → NP_001031116.1  multidrug resistance-associated protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24635, Q8RX76, Q9C8G9, Q9SAQ1
      UniProtKB/TrEMBL
      A0A178WBV0, A0A5S9WDU0, A0A7G2DWV7
      Conserved Domains (1) summary
      PLN03130
      Location:1 → 1622
      PLN03130; ABC transporter C family member; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C8G9.1

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