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    ALB4 OxaA/YidC-like membrane insertion protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839065, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALB4
    Official Full Name
    OxaA/YidC-like membrane insertion protein
    Primary source
    TAIR:AT1G24490
    Locus tag
    AT1G24490
    See related
    Araport:AT1G24490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALBINA 4; ARABIDOPSIS THALIANA ENVELOPE MEMBRANE INTEGRASE; ARTEMIS; F21J9.16
    Summary
    Homologue of the Alb3/Oxa1/YidC family. ALB4 is almost identical to the Alb3/Oxa1/YidC domain of the previously described 110 kDa inner envelope protein ARTEMIS. However, ALB4 is expressed as a separate 55 kDa protein and is located in the thylakoid membrane of chloroplasts. Analysis of a T-DNA insertion line with a reduced level of Alb4 revealed chloroplasts with an altered ultrastructure. Mutant plastids are larger, more spherical in appearance and the grana stacks within the mutant lines are less appressed than in the wild-type chloroplasts. ALB4 is required for proper chloroplast biogenesis.
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    Genomic context

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    See ALB4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (8682195..8685271)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene beta-ketoacyl reductase 2 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ER protein carbohydrate-binding protein Neighboring gene TCP-1/cpn60 chaperonin family protein Neighboring gene homolog of Brassica campestris pollen protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A second thylakoid membrane-localized Alb3/OxaI/YidC homologue is involved in proper chloroplast biogenesis in Arabidopsis thaliana. Gerdes L, et al. J Biol Chem, 2006 Jun 16. PMID 16595657
    2. Suppressors of the Chloroplast Protein Import Mutant tic40 Reveal a Genetic Link between Protein Import and Thylakoid Biogenesis. Bédard J, et al. Plant Cell, 2017 Jul. PMID 28684427, Free PMC Article
    3. Genetic and Physical Interaction Studies Reveal Functional Similarities between ALBINO3 and ALBINO4 in Arabidopsis. Trösch R, et al. Plant Physiol, 2015 Oct. PMID 26265777, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ALB4 and STIC2 both participate in thylakoid protein targeting
      Title: Suppressors of the Chloroplast Protein Import Mutant tic40 Reveal a Genetic Link between Protein Import and Thylakoid Biogenesis.
    2. ALB4 optimizes the insertion of thylakoid proteins by participating in the ALB3-chloroplast signal recognition particle pathway.
      Title: Genetic and Physical Interaction Studies Reveal Functional Similarities between ALBINO3 and ALBINO4 in Arabidopsis.
    3. Alb3 has a role in insertion of a subset of the light-harvesting chlorophyll-binding proteins, while Alb4 is required for proper chloroplast biogenesis
      Title: A second thylakoid membrane-localized Alb3/OxaI/YidC homologue is involved in proper chloroplast biogenesis in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001160892.1
    NM_102294.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables membrane insertase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to chloroplast IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    OxaA/YidC-like membrane insertion protein
    NP_001154364.1
    • ALBINA 4 (ALB4); CONTAINS InterPro DOMAIN/s: Membrane insertion protein, OxaA/YidC (InterPro:IPR001708), Membrane insertion protein, OxaA/YidC, core (InterPro:IPR020001); BEST Arabidopsis thaliana protein match is: 63 kDa inner membrane family protein (TAIR:AT2G28800.1); Has 8058 Blast hits to 8029 proteins in 2465 species: Archae - 0; Bacteria - 5573; Metazoa - 87; Fungi - 22; Plants - 115; Viruses - 0; Other Eukaryotes - 2261 (source: NCBI BLink).
    NP_173858.5
    • ALBINA 4 (ALB4); CONTAINS InterPro DOMAIN/s: Membrane insertion protein, OxaA/YidC (InterPro:IPR001708), Membrane insertion protein, OxaA/YidC, core (InterPro:IPR020001); BEST Arabidopsis thaliana protein match is: 63 kDa inner membrane family protein (TAIR:AT2G28800.1); Has 8883 Blast hits to 8828 proteins in 2598 species: Archae - 0; Bacteria - 5941; Metazoa - 162; Fungi - 75; Plants - 144; Viruses - 0; Other Eukaryotes - 2561 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8682195..8685271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102294.7 → NP_173858.5  OxaA/YidC-like membrane insertion protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173858.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1RPP7, Q9FYL3, Q9FYL4
      UniProtKB/TrEMBL
      A0A178W2M5
      Conserved Domains (2) summary
      PRK00247
      Location:123 → 480
      PRK00247; putative inner membrane protein translocase component YidC; Validated
      pfam02096
      Location:124 → 338
      60KD_IMP; 60Kd inner membrane protein

    2. NM_001160892.1 → NP_001154364.1  OxaA/YidC-like membrane insertion protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W2M5, F4I9A9
      Conserved Domains (1) summary
      pfam02096
      Location:112 → 301
      60KD_IMP; 60Kd inner membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FYL3.3

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