SECA2 Preprotein translocase SecA family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: SECA2
Gene description: Preprotein translocase SecA family protein
Primary source: Araport:AT1G21650
Locus tag: AT1G21650
See related: TAIR:AT1G21650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F8K7.7; F8K7_7
Summary: Encodes a component of the thylakoid-localized Sec system involved in the translocation of cytoplasmic proteins into plastid. Loss-of-function mutations result in arrest at the globular stage and embryo lethality.
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Genomic context

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See SECA2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 37

Sequence:: Chromosome: 1; NC_003070.9 (7592664..7604229, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the SEC2 translocase consisting of SCY2, SECE2, and SECA2 likely integrates a subset of inner envelope membrane proteins.
Title: Identification of Putative Substrates of SEC2, a Chloroplast Inner Envelope Translocase.
SCY2 and SECA2 function in Sec-mediated integration and translocation processes at the inner envelope membrane. [SECA2]
Title: Plastids contain a second sec translocase system with essential functions.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001198129.1

Supported by ESTs:

NM_001198130.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables chloroplast protein-transporting ATPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein import	IEA Inferred from Electronic Annotation more info
involved_in protein targeting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plastid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Preprotein translocase SecA family protein

NP_001185058.1

Preprotein translocase SecA family protein; FUNCTIONS IN: ATPase activity, zinc ion binding, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, ATP binding; INVOLVED IN: intracellular protein transport, protein targeting, protein transport by the Sec complex, protein import; LOCATED IN: internal side of plasma membrane, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), Zinc finger, RING-type (InterPro:IPR001841), SecA, preprotein translocase (InterPro:IPR022491), WD40 repeat (InterPro:IPR001680), SecA motor DEAD (InterPro:IPR014018), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), SecA Wing/Scaffold (InterPro:IPR011116), WD40-repeat-containing domain (InterPro:IPR017986), SecA preprotein, cross-linking domain (InterPro:IPR011130), SecA DEAD-like (InterPro:IPR011115), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), SecA conserved site (InterPro:IPR020937), WD40 repeat, subgroup (InterPro:IPR019781), SecA protein (InterPro:IPR000185); BEST Arabidopsis thaliana protein match is: zinc ion binding (TAIR:AT1G21651.1).

NP_001185059.1

Preprotein translocase SecA family protein; FUNCTIONS IN: ATPase activity, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, ATP binding; INVOLVED IN: intracellular protein transport, protein targeting, protein import, protein transport by the Sec complex; LOCATED IN: internal side of plasma membrane, chloroplast, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SecA Wing/Scaffold (InterPro:IPR011116), SecA preprotein, cross-linking domain (InterPro:IPR011130), SecA, preprotein translocase (InterPro:IPR022491), SecA DEAD-like (InterPro:IPR011115), SecA conserved site (InterPro:IPR020937), SecA motor DEAD (InterPro:IPR014018), SecA protein (InterPro:IPR000185); BEST Arabidopsis thaliana protein match is: Albino or Glassy Yellow 1 (TAIR:AT4G01800.1).

NP_173584.5

Preprotein translocase SecA family protein; FUNCTIONS IN: ATPase activity, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, ATP binding; INVOLVED IN: intracellular protein transport, protein targeting, protein transport by the Sec complex, protein import; LOCATED IN: internal side of plasma membrane, chloroplast, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SecA, preprotein translocase (InterPro:IPR022491), SecA motor DEAD (InterPro:IPR014018), SecA Wing/Scaffold (InterPro:IPR011116), SecA preprotein, cross-linking domain (InterPro:IPR011130), SecA conserved site (InterPro:IPR020937), SecA DEAD-like (InterPro:IPR011115), SecA protein (InterPro:IPR000185); BEST Arabidopsis thaliana protein match is: Albino or Glassy Yellow 1 (TAIR:AT4G01800.1); Has 21976 Blast hits to 13078 proteins in 2820 species: Archae - 0; Bacteria - 13647; Metazoa - 53; Fungi - 1; Plants - 97; Viruses - 0; Other Eukaryotes - 8178 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

7592664..7604229 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102014.6 → NP_173584.5 Preprotein translocase SecA family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173584.5

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WEE9

Conserved Domains (5) summary

PRK12904
Location:75 → 1037

PRK12904; preprotein translocase subunit SecA; Reviewed

pfam01043
Location:301 → 407

SecA_PP_bind; SecA preprotein cross-linking domain

pfam07516
Location:770 → 1039

SecA_SW; SecA Wing and Scaffold domain

cl00947
Location:77 → 149

L-fuc_L-ara-isomerases; L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose ...

cl21455
Location:482 → 564

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001198129.1 → NP_001185058.1 Preprotein translocase SecA family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185058.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9VGN8, F4HY36

Conserved Domains (8) summary

COG2319
Location:509 → 805

WD40; WD40 repeat [General function prediction only]

PRK12904
Location:818 → 1791

PRK12904; preprotein translocase subunit SecA; Reviewed

pfam01043
Location:1048 → 1154

SecA_PP_bind; SecA preprotein cross-linking domain

pfam07516
Location:1517 → 1793

SecA_SW; SecA Wing and Scaffold domain

pfam14634
Location:5 → 50

zf-RING_5; zinc-RING finger domain

sd00039
Location:527 → 562

7WD40; WD40 repeat [structural motif]

cl02567
Location:521 → 805

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl21455
Location:1229 → 1311

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001198130.1 → NP_001185059.1 Preprotein translocase SecA family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185059.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D8WUA4, F4HY37, Q9XI14

UniProtKB/TrEMBL

A0A178WEE9

Conserved Domains (5) summary

PRK12904
Location:75 → 1044

PRK12904; preprotein translocase subunit SecA; Reviewed

pfam01043
Location:301 → 407

SecA_PP_bind; SecA preprotein cross-linking domain

pfam07516
Location:770 → 1046

SecA_SW; SecA Wing and Scaffold domain

cl00947
Location:77 → 149

L-fuc_L-ara-isomerases; L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose ...

cl21455
Location:482 → 564

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases