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    FNR2 ferredoxin-NADP[+]-oxidoreductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838591, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FNR2
    Official Full Name
    ferredoxin-NADP[+]-oxidoreductase 2
    Primary source
    TAIR:AT1G20020
    Locus tag
    AT1G20020
    See related
    Araport:AT1G20020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATLFNR2; ferredoxin-NADP(+)-oxidoreductase 2; FERREDOXIN:NADP(H) OXIDOREDUCTASE; LEAF FNR 2; leaf-type chloroplast-targeted FNR 2; LFNR2; T20H2.20; T20H2_20
    Summary
    Encodes a leaf-type ferredoxin:NADP(H) oxidoreductase. It is present in both chloroplast stroma and thylakoid membranes but is more abundant in the stroma
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    Genomic context

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    See FNR2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (6942625..6945091)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pathogenesis-related thaumatin superfamily protein Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions. Kramer M, et al. Elife, 2021 Mar 9. PMID 33685582, Free PMC Article
    2. Comparative analysis of leaf-type ferredoxin-NADP oxidoreductase isoforms in Arabidopsis thaliana. Lintala M, et al. Plant J, 2009 Mar. PMID 19054362
    3. Posttranslational modifications of FERREDOXIN-NADP+ OXIDOREDUCTASE in Arabidopsis chloroplasts. Lehtimäki N, et al. Plant Physiol, 2014 Dec. PMID 25301888, Free PMC Article
    4. Arabidopsis Tic62 and ferredoxin-NADP(H) oxidoreductase form light-regulated complexes that are integrated into the chloroplast redox poise. Benz JP, et al. Plant Cell, 2009 Dec. PMID 20040542, Free PMC Article
    5. A complex containing PGRL1 and PGR5 is involved in the switch between linear and cyclic electron flow in Arabidopsis. DalCorso G, et al. Cell, 2008 Jan 25. PMID 18243102

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions.
      Title: Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions.
    2. The dynamic, multilayer regulation of AtFNR exemplifies the complex regulatory network systems controlling chloroplast proteins by a range of posttranslational modifications.
      Title: Posttranslational modifications of FERREDOXIN-NADP+ OXIDOREDUCTASE in Arabidopsis chloroplasts.
    3. FNR2 mutants have enhanced tolerance against oxidative stress and low temperatures.
      Title: Comparative analysis of leaf-type ferredoxin-NADP oxidoreductase isoforms in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084097.1
    NM_001332422.1
    NM_101857.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADPH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		  
    enables ferredoxin-NADP+ reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in photosynthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		  
    located_in chloroplast thylakoid HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of chloroplast thylakoid membrane protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

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    Preferred Names
    ferredoxin-NADP[+]-oxidoreductase 2
    NP_001077566.1
    • LEAF FNR 2 (ATLFNR2); FUNCTIONS IN: oxidoreductase activity, poly(U) RNA binding, NADPH dehydrogenase activity; INVOLVED IN: oxidation reduction, defense response to fungus, incompatible interaction, defense response to bacterium; LOCATED IN: thylakoid, chloroplast thylakoid membrane, apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Oxidoreductase, FAD-binding domain (InterPro:IPR008333), Ferredoxin--NADP reductase (InterPro:IPR012146), Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferredoxin Reductase (InterPro:IPR015701), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709); BEST Arabidopsis thaliana protein match is: ferredoxin-NADP(+)-oxidoreductase 1 (TAIR:AT5G66190.1); Has 6779 Blast hits to 6779 proteins in 1702 species: Archae - 20; Bacteria - 3601; Metazoa - 804; Fungi - 729; Plants - 614; Viruses - 0; Other Eukaryotes - 1011 (source: NCBI BLink).
    NP_001319047.1
    • LEAF FNR 2 (ATLFNR2); FUNCTIONS IN: oxidoreductase activity, poly(U) RNA binding, NADPH dehydrogenase activity; INVOLVED IN: oxidation reduction, defense response to fungus, incompatible interaction, defense response to bacterium; LOCATED IN: thylakoid, chloroplast thylakoid membrane, apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferredoxin Reductase (InterPro:IPR015701), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), Ferredoxin--NADP reductase (InterPro:IPR012146); BEST Arabidopsis thaliana protein match is: ferredoxin-NADP(+)-oxidoreductase 1 (TAIR:AT5G66190.1); Has 6542 Blast hits to 6542 proteins in 1635 species: Archae - 18; Bacteria - 3429; Metazoa - 796; Fungi - 693; Plants - 607; Viruses - 0; Other Eukaryotes - 999 (source: NCBI BLink).
    NP_173431.1
    • ferredoxin-NADP(+)-oxidoreductase 2 (FNR2); FUNCTIONS IN: oxidoreductase activity, poly(U) RNA binding, NADPH dehydrogenase activity; INVOLVED IN: oxidation reduction, defense response to fungus, incompatible interaction, defense response to bacterium; LOCATED IN: thylakoid, chloroplast thylakoid membrane, apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Oxidoreductase, FAD-binding domain (InterPro:IPR008333), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferredoxin Reductase (InterPro:IPR015701), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), Ferredoxin--NADP reductase (InterPro:IPR012146); BEST Arabidopsis thaliana protein match is: ferredoxin-NADP(+)-oxidoreductase 1 (TAIR:AT5G66190.1); Has 6774 Blast hits to 6774 proteins in 1708 species: Archae - 20; Bacteria - 3604; Metazoa - 802; Fungi - 759; Plants - 616; Viruses - 0; Other Eukaryotes - 973 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6942625..6945091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101857.6 → NP_173431.1  ferredoxin-NADP[+]-oxidoreductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173431.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRF7, A8MRG5, Q8W493, Q9LNS9
      UniProtKB/TrEMBL
      A0A178WE91, A0A5S9VAW4
      Conserved Domains (1) summary
      PLN03115
      Location:1 → 369
      PLN03115; ferredoxin--NADP(+) reductase; Provisional

    2. NM_001332422.1 → NP_001319047.1  ferredoxin-NADP[+]-oxidoreductase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z2A8

    3. NM_001084097.1 → NP_001077566.1  ferredoxin-NADP[+]-oxidoreductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W493
      Conserved Domains (2) summary
      cd06208
      Location:85 → 369
      CYPOR_like_FNR; These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer ...
      PLN03115
      Location:1 → 369
      PLN03115; ferredoxin--NADP(+) reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W493.1

    Gene LinkOut

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